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Biological and Environmental Research Ontology
Last uploaded:
December 23, 2022
| Id | http://purl.obolibrary.org/obo/NCIT_C827
http://purl.obolibrary.org/obo/NCIT_C827
|
|---|---|
| Preferred Name | Semustine |
| Definitions |
A methylated derivative of carmustine with antineoplastic activity. As an alkylating agent, semustine forms covalent linkages with nucleophilic centers in DNA, causing depurination, base-pair miscoding, strand scission, and DNA-DNA cross-linking, which may result in cytotoxicity. (NCI04)
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| Type | http://www.w3.org/2002/07/owl#Class |
All Properties
| definition | A methylated derivative of carmustine with antineoplastic activity. As an alkylating agent, semustine forms covalent linkages with nucleophilic centers in DNA, causing depurination, base-pair miscoding, strand scission, and DNA-DNA cross-linking, which may result in cytotoxicity. (NCI04) |
|---|---|
| prefLabel | Semustine
|
| label | Semustine
|
| PDQ_Closed_Trial_Search_ID | 43727
|
| code | C827
|
| prefixIRI | NCIT:C827
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| in_subset | |
| Preferred_Name | Semustine
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| FDA_UNII_Code | 6YY7T1T567
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| Contributing_Source | FDA
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| Maps_To | Semustine
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| CAS_Registry | 13909-09-6
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| NSC Number | 95441
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| NCI_Drug_Dictionary_ID | 43727
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| Legacy Concept Name | Semustine
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| type | |
| ALT_DEFINITION | An anticancer drug that belongs to the family of drugs called alkylating agents.
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| Is_Value_For_GDC_Property | |
| subClassOf | |
| PDQ_Open_Trial_Search_ID | 43727
|
| Semantic_Type |
Organic Chemical
Pharmacologic Substance
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| UMLS_CUI | C0036637
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