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Biological and Environmental Research Ontology
Last uploaded:
December 23, 2022
| Id | http://purl.obolibrary.org/obo/NCIT_C82694
http://purl.obolibrary.org/obo/NCIT_C82694
|
|---|---|
| Preferred Name | Eg5 Kinesin-Related Motor Protein Inhibitor ARQ 621 |
| Definitions |
A small-molecule inhibitor of the kinesin-related motor protein Eg5 with potential antineoplastic activity. Eg5 kinesin-related motor protein inhibitor ARQ 621 selectively inhibits the activity of Eg5, which may result in mitotic disruption, apoptosis and cell death. The ATP-dependent Eg5 kinesin-related motor protein (also known as KIF11 or kinesin spindle protein-5) is a plus-end directed kinesin motor protein involved in the regulation of spindle dynamics, including assembly and maintenance, during mitosis.
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| Type | http://www.w3.org/2002/07/owl#Class |
All Properties
| definition | A small-molecule inhibitor of the kinesin-related motor protein Eg5 with potential antineoplastic activity. Eg5 kinesin-related motor protein inhibitor ARQ 621 selectively inhibits the activity of Eg5, which may result in mitotic disruption, apoptosis and cell death. The ATP-dependent Eg5 kinesin-related motor protein (also known as KIF11 or kinesin spindle protein-5) is a plus-end directed kinesin motor protein involved in the regulation of spindle dynamics, including assembly and maintenance, during mitosis. |
|---|---|
| prefLabel | Eg5 Kinesin-Related Motor Protein Inhibitor ARQ 621
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| label | Eg5 Kinesin-Related Motor Protein Inhibitor ARQ 621
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| NCI_META_CUI | CL388484
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| PDQ_Closed_Trial_Search_ID | 634612
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| code | C82694
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| prefixIRI | NCIT:C82694
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| in_subset | |
| Preferred_Name | Eg5 Kinesin-Related Motor Protein Inhibitor ARQ 621
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| Maps_To | Eg5 Kinesin-Related Motor Protein Inhibitor ARQ 621
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| NCI_Drug_Dictionary_ID | 634612
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| Legacy Concept Name | Eg5_Kinesin-Related_Motor_Protein_Inhibitor_ARQ_621
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| type | |
| Is_Value_For_GDC_Property | |
| subClassOf | |
| PDQ_Open_Trial_Search_ID | 634612
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| Semantic_Type | Pharmacologic Substance
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