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Biological and Environmental Research Ontology
Last uploaded:
December 23, 2022
| Id | http://purl.obolibrary.org/obo/NCIT_C82686
http://purl.obolibrary.org/obo/NCIT_C82686
|
|---|---|
| Preferred Name | Anti-AGS-8 Monoclonal Antibody AGS-8M4 |
| Definitions |
A humanized monoclonal antibody directed against the activator of g-proteins signaling (AGS) cell surface protein AGS-8 with potential antineoplastic activity. Anti-AGS-8 monoclonal antibody AGS-8M4 selectively binds to AGS-8, triggering complement-dependent cell lysis and antibody-dependent cell-mediated cytotoxicity in tumor cells expressing AGS-8. While normally expressed at low levels in the heart in response to ischemia, AGS-8 has been found to be expressed in more than 70% of ovarian neoplasms.
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| Type | http://www.w3.org/2002/07/owl#Class |
All Properties
| definition | A humanized monoclonal antibody directed against the activator of g-proteins signaling (AGS) cell surface protein AGS-8 with potential antineoplastic activity. Anti-AGS-8 monoclonal antibody AGS-8M4 selectively binds to AGS-8, triggering complement-dependent cell lysis and antibody-dependent cell-mediated cytotoxicity in tumor cells expressing AGS-8. While normally expressed at low levels in the heart in response to ischemia, AGS-8 has been found to be expressed in more than 70% of ovarian neoplasms. |
|---|---|
| prefLabel | Anti-AGS-8 Monoclonal Antibody AGS-8M4
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| label | Anti-AGS-8 Monoclonal Antibody AGS-8M4
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| NCI_META_CUI | CL388473
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| PDQ_Closed_Trial_Search_ID | 633505
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| code | C82686
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| Has_Target | |
| prefixIRI | NCIT:C82686
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| in_subset |
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| Display_Name | Anti-AGS-8 Monoclonal Antibody AGS-8M4
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| Preferred_Name | Anti-AGS-8 Monoclonal Antibody AGS-8M4
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| Contributing_Source | CTRP
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| Maps_To | Anti-AGS-8 Monoclonal Antibody AGS-8M4
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| NCI_Drug_Dictionary_ID | 633505
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| Legacy Concept Name | Anti-AGS-8_Monoclonal_Antibody_AGS-8M4
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| type | |
| Is_Value_For_GDC_Property | |
| subClassOf | |
| PDQ_Open_Trial_Search_ID | 633505
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| Semantic_Type |
Amino Acid, Peptide, or Protein
Immunologic Factor
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