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Biological and Environmental Research Ontology
Last uploaded:
December 23, 2022
| Id | http://purl.obolibrary.org/obo/NCIT_C82674
http://purl.obolibrary.org/obo/NCIT_C82674
|
|---|---|
| Preferred Name | Aurora B Serine/Threonine Kinase Inhibitor TAK-901 |
| Definitions |
A small-molecule inhibitor of the serine-threonine kinase Aurora B with potential antineoplastic activity. Aurora B kinase inhibitor TAK-901 binds to and inhibits the activity of Aurora B, which may result in a decrease in the proliferation of tumor cells that overexpress Aurora B. Aurora B is a positive regulator of mitosis that functions in the attachment of the mitotic spindle to the centromere; the segregation of sister chromatids to each daughter cell; and the separation of daughter cells during cytokinesis. This serine/threonine kinase may be amplified and overexpressed by a variety of cancer cell types.
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| Type | http://www.w3.org/2002/07/owl#Class |
All Properties
| definition | A small-molecule inhibitor of the serine-threonine kinase Aurora B with potential antineoplastic activity. Aurora B kinase inhibitor TAK-901 binds to and inhibits the activity of Aurora B, which may result in a decrease in the proliferation of tumor cells that overexpress Aurora B. Aurora B is a positive regulator of mitosis that functions in the attachment of the mitotic spindle to the centromere; the segregation of sister chromatids to each daughter cell; and the separation of daughter cells during cytokinesis. This serine/threonine kinase may be amplified and overexpressed by a variety of cancer cell types. |
|---|---|
| prefLabel | Aurora B Serine/Threonine Kinase Inhibitor TAK-901
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| label | Aurora B Serine/Threonine Kinase Inhibitor TAK-901
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| PDQ_Closed_Trial_Search_ID | 632219
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| code | C82674
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| Has_Target | |
| prefixIRI | NCIT:C82674
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| in_subset |
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| Display_Name | Aurora B Serine/Threonine Kinase Inhibitor TAK-901
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| Preferred_Name | Aurora B Serine/Threonine Kinase Inhibitor TAK-901
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| FDA_UNII_Code | DM9UIR23R7
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| Contributing_Source |
CTRP
FDA
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| Maps_To | Aurora B Serine/Threonine Kinase Inhibitor TAK-901
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| CAS_Registry | 934541-31-8
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| NCI_Drug_Dictionary_ID | 632219
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| Legacy Concept Name | Aurora_B_Serine_Threonine_Kinase_Inhibitor_TAK-901
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| type | |
| Is_Value_For_GDC_Property | |
| subClassOf | |
| PDQ_Open_Trial_Search_ID | 632219
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| Semantic_Type | Pharmacologic Substance
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| UMLS_CUI | C2826371
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