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Biological and Environmental Research Ontology
Last uploaded:
December 23, 2022
| Id | http://purl.obolibrary.org/obo/NCIT_C82657
http://purl.obolibrary.org/obo/NCIT_C82657
|
|---|---|
| Preferred Name | Beta-Glucan MM-10-001 |
| Definitions |
A powder formulation containing a triple helix beta-glucan, isolated from the cell walls of the shiitake mushroom (Lentinula edodes), with potential immunostimulating activity. The beta-glucan in beta-glucan MM-10-001 binds to a lectin site within the complement receptor 3 (CR3 or iC3b receptor) on leukocytes, priming the receptor to trigger cytotoxic degranulation of leukocytes when leukocyte CR3 binds to iC3b-opsonized tumor cells. iC3b is the proteolyticly inactive product of the complement cleavage fragment C3b.
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| Type | http://www.w3.org/2002/07/owl#Class |
All Properties
| definition | A powder formulation containing a triple helix beta-glucan, isolated from the cell walls of the shiitake mushroom (Lentinula edodes), with potential immunostimulating activity. The beta-glucan in beta-glucan MM-10-001 binds to a lectin site within the complement receptor 3 (CR3 or iC3b receptor) on leukocytes, priming the receptor to trigger cytotoxic degranulation of leukocytes when leukocyte CR3 binds to iC3b-opsonized tumor cells. iC3b is the proteolyticly inactive product of the complement cleavage fragment C3b. |
|---|---|
| prefLabel | Beta-Glucan MM-10-001
|
| label | Beta-Glucan MM-10-001
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| NCI_META_CUI | CL388490
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| PDQ_Closed_Trial_Search_ID | 636186
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| code | C82657
|
| prefixIRI | NCIT:C82657
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| in_subset |
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| Display_Name | Beta-Glucan MM-10-001
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| Preferred_Name | Beta-Glucan MM-10-001
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| Contributing_Source | CTRP
|
| Maps_To | Beta-Glucan MM-10-001
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| NCI_Drug_Dictionary_ID | 636186
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| Legacy Concept Name | Beta-Glucan_MM-10-001
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| type | |
| Is_Value_For_GDC_Property | |
| subClassOf | |
| PDQ_Open_Trial_Search_ID | 636186
|
| Semantic_Type |
Organic Chemical
Pharmacologic Substance
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