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Biological and Environmental Research Ontology
Last uploaded:
December 23, 2022
| Id | http://purl.obolibrary.org/obo/NCIT_C82600
http://purl.obolibrary.org/obo/NCIT_C82600
|
|---|---|
| Preferred Name | Deslorelin Acetate |
| Definitions |
A synthetic nonapeptide analogue of the natural gonadotrophin releasing hormone (GnRH) with potential antineoplastic activity. Deslorelin binds to and activates pituitary gonadotropin releasing hormone (GnRH) receptors. Continuous, prolonged administration of goserelin in males results in pituitary GnRH receptor desensitization and inhibition of pituitary secretion of follicle stimulating hormone (FSH) and luteinizing hormone (LH), leading to a significant decline in testosterone production; in females, prolonged administration results in a decrease in estradiol production. (NCI04)
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| Type | http://www.w3.org/2002/07/owl#Class |
All Properties
| definition | A synthetic nonapeptide analogue of the natural gonadotrophin releasing hormone (GnRH) with potential antineoplastic activity. Deslorelin binds to and activates pituitary gonadotropin releasing hormone (GnRH) receptors. Continuous, prolonged administration of goserelin in males results in pituitary GnRH receptor desensitization and inhibition of pituitary secretion of follicle stimulating hormone (FSH) and luteinizing hormone (LH), leading to a significant decline in testosterone production; in females, prolonged administration results in a decrease in estradiol production. (NCI04) |
|---|---|
| prefLabel | Deslorelin Acetate
|
| label | Deslorelin Acetate
|
| PDQ_Closed_Trial_Search_ID | 357620
|
| code | C82600
|
| prefixIRI | NCIT:C82600
|
| in_subset | |
| Preferred_Name | Deslorelin Acetate
|
| FDA_UNII_Code | 679007NR5C
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| Contributing_Source | FDA
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| Chemical_Formula | C64H83N17O12.C2H4O2
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| Maps_To | Deslorelin Acetate
|
| CAS_Registry | 82318-06-7
|
| NCI_Drug_Dictionary_ID | 357620
|
| Legacy Concept Name | Deslorelin_Acetate
|
| Has_Free_Acid_Or_Base_Form | |
| type | |
| Is_Value_For_GDC_Property | |
| subClassOf | |
| PDQ_Open_Trial_Search_ID | 357620
|
| Semantic_Type |
Organic Chemical
Pharmacologic Substance
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| UMLS_CUI | C0378714
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