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Biological and Environmental Research Ontology
Last uploaded:
December 23, 2022
| Id | http://purl.obolibrary.org/obo/NCIT_C82414
http://purl.obolibrary.org/obo/NCIT_C82414
|
|---|---|
| Preferred Name | Actinium Ac 225 Lintuzumab |
| Definitions |
A radioimmunoconjugate consisting of the humanized monoclonal antibody lintuzumab conjugated to the alpha-emitting radioisotope actinium Ac 225 with potential antineoplastic activity. The monoclonal antibody moiety of actinium Ac 225 lintuzumab specifically binds to the cell surface antigen CD33 antigen, delivering a cytotoxic dose of alpha radiation to cells expressing CD33. CD33 is a cell surface antigen expressed on normal non-pluripotent hematopoietic stem cells and overexpressed on myeloid leukemia cells.
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| Type | http://www.w3.org/2002/07/owl#Class |
All Properties
| definition | A radioimmunoconjugate consisting of the humanized monoclonal antibody lintuzumab conjugated to the alpha-emitting radioisotope actinium Ac 225 with potential antineoplastic activity. The monoclonal antibody moiety of actinium Ac 225 lintuzumab specifically binds to the cell surface antigen CD33 antigen, delivering a cytotoxic dose of alpha radiation to cells expressing CD33. CD33 is a cell surface antigen expressed on normal non-pluripotent hematopoietic stem cells and overexpressed on myeloid leukemia cells. |
|---|---|
| prefLabel | Actinium Ac 225 Lintuzumab
|
| label | Actinium Ac 225 Lintuzumab
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| NCI_META_CUI | CL408677
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| PDQ_Closed_Trial_Search_ID | 637163
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| code | C82414
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| prefixIRI | NCIT:C82414
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| in_subset | |
| Preferred_Name | Actinium Ac 225 Lintuzumab
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| FDA_UNII_Code | V860J30J9N
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| Contributing_Source | FDA
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| Maps_To | Actinium Ac 225 Lintuzumab
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| CAS_Registry | 2209911-94-2
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| NCI_Drug_Dictionary_ID | 637163
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| Legacy Concept Name | Actinium_Ac_225_Lintuzumab
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| type | |
| Is_Value_For_GDC_Property | |
| subClassOf | |
| PDQ_Open_Trial_Search_ID | 637163
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| Semantic_Type |
Amino Acid, Peptide, or Protein
Pharmacologic Substance
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