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Biological and Environmental Research Ontology
Last uploaded:
December 23, 2022
| Id | http://purl.obolibrary.org/obo/NCIT_C82411
http://purl.obolibrary.org/obo/NCIT_C82411
|
|---|---|
| Preferred Name | Immunocytokine NHS-IL2-LT |
| Definitions |
A fusion protein consisting of a mouse-human chimeric antibody directed against DNA released by necrotic tumor cells fused to two molecules of a genetically modified human interleukin-2 (IL-2) with potential antineoplastic activity. Upon administration, the antibody moiety of immunocytokine NHS-IL2-LT binds to DNA released by necrotic tumor cells located primarily at the core of necrotic solid tumors, delivering the IL-2 moiety. In turn, the IL-2 moiety of this agent activates the immune system to mount a cytotoxic T lymphocyte response against nearby tumor cells.
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| Type | http://www.w3.org/2002/07/owl#Class |
All Properties
| definition | A fusion protein consisting of a mouse-human chimeric antibody directed against DNA released by necrotic tumor cells fused to two molecules of a genetically modified human interleukin-2 (IL-2) with potential antineoplastic activity. Upon administration, the antibody moiety of immunocytokine NHS-IL2-LT binds to DNA released by necrotic tumor cells located primarily at the core of necrotic solid tumors, delivering the IL-2 moiety. In turn, the IL-2 moiety of this agent activates the immune system to mount a cytotoxic T lymphocyte response against nearby tumor cells. |
|---|---|
| prefLabel | Immunocytokine NHS-IL2-LT
|
| label | Immunocytokine NHS-IL2-LT
|
| PDQ_Closed_Trial_Search_ID | 641919
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| code | C82411
|
| prefixIRI | NCIT:C82411
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| in_subset |
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| Display_Name | Interleukin-2 Fusion Protein MSB0010445
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| Preferred_Name | Immunocytokine NHS-IL2-LT
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| FDA_UNII_Code | EI74F49ZLJ
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| Contributing_Source |
CTRP
FDA
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| Maps_To | Immunocytokine NHS-IL2-LT
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| CAS_Registry | 1223034-72-7
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| NCI_Drug_Dictionary_ID | 641919
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| Legacy Concept Name | Selectikine
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| type | |
| Is_Value_For_GDC_Property | |
| subClassOf | |
| PDQ_Open_Trial_Search_ID | 641919
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| Semantic_Type |
Amino Acid, Peptide, or Protein
Pharmacologic Substance
Immunologic Factor
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| UMLS_CUI | C2830085
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