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Biological and Environmental Research Ontology
Last uploaded:
December 23, 2022
| Id | http://purl.obolibrary.org/obo/NCIT_C82404
http://purl.obolibrary.org/obo/NCIT_C82404
|
|---|---|
| Preferred Name | PIM Kinase Inhibitor SGI-1776 |
| Definitions |
A small-molecule pan-PIM protein kinase inhibitor with potential antineoplastic activity. PIM kinase inhibitor SGI-1776 binds to and inhibits the activities of PIM-1, -2 and -3 serine/threonine kinases, which may result in the interruption of the G1/S phase cell cycle transition, the expression of pro-apoptotic Bcl2 proteins and tumor cell apoptosis. PIM kinases play key roles in cell cycle progression and apoptosis inhibition and may be overexpressed in various malignancies.
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| Type | http://www.w3.org/2002/07/owl#Class |
All Properties
| definition | A small-molecule pan-PIM protein kinase inhibitor with potential antineoplastic activity. PIM kinase inhibitor SGI-1776 binds to and inhibits the activities of PIM-1, -2 and -3 serine/threonine kinases, which may result in the interruption of the G1/S phase cell cycle transition, the expression of pro-apoptotic Bcl2 proteins and tumor cell apoptosis. PIM kinases play key roles in cell cycle progression and apoptosis inhibition and may be overexpressed in various malignancies. |
|---|---|
| prefLabel | PIM Kinase Inhibitor SGI-1776
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| label | PIM Kinase Inhibitor SGI-1776
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| PDQ_Closed_Trial_Search_ID | 638088
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| code | C82404
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| Has_Target | |
| prefixIRI | NCIT:C82404
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| in_subset |
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| Display_Name | PIM Kinase Inhibitor SGI-1776
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| Preferred_Name | PIM Kinase Inhibitor SGI-1776
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| FDA_UNII_Code | 72AUA0603W
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| Contributing_Source |
CTRP
FDA
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| Maps_To | PIM Kinase Inhibitor SGI-1776
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| CAS_Registry | 1025065-69-3
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| NCI_Drug_Dictionary_ID | 638088
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| Legacy Concept Name | Pim_Kinase_Inhibitor_SGI-1776
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| type | |
| Is_Value_For_GDC_Property | |
| subClassOf | |
| PDQ_Open_Trial_Search_ID | 638088
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| Semantic_Type | Pharmacologic Substance
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| UMLS_CUI | C2742218
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