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Biological and Environmental Research Ontology
Last uploaded:
December 23, 2022
| Id | http://purl.obolibrary.org/obo/NCIT_C82398
http://purl.obolibrary.org/obo/NCIT_C82398
|
|---|---|
| Preferred Name | Pixantrone Dimaleate |
| Definitions |
The dimaleate salt of a synthetic, noncardiotoxic aza-anthracenedione analogue with potential antineoplastic activity. Pixantrone intercalates into DNA and induces topoisomerase II-mediated DNA strand crosslinks, resulting in inhibition of DNA replication and tumor cell cytotoxicity.
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| Type | http://www.w3.org/2002/07/owl#Class |
All Properties
| definition | The dimaleate salt of a synthetic, noncardiotoxic aza-anthracenedione analogue with potential antineoplastic activity. Pixantrone intercalates into DNA and induces topoisomerase II-mediated DNA strand crosslinks, resulting in inhibition of DNA replication and tumor cell cytotoxicity. |
|---|---|
| prefLabel | Pixantrone Dimaleate
|
| label | Pixantrone Dimaleate
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| NCI_META_CUI | CL408667
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| PDQ_Closed_Trial_Search_ID | 269678
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| code | C82398
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| Has_Target | |
| prefixIRI | NCIT:C82398
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| in_subset |
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| Display_Name | Pixantrone Dimaleate
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| Preferred_Name | Pixantrone Dimaleate
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| FDA_UNII_Code | P0R64C4CR9
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| Contributing_Source |
CTRP
FDA
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| Chemical_Formula | C17H19N5O2.2C4H4O4
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| Maps_To | Pixantrone Dimaleate
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| CAS_Registry | 144675-97-8
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| NCI_Drug_Dictionary_ID | 269678
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| Legacy Concept Name | Pixantrone_Dimaleate
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| Has_Free_Acid_Or_Base_Form | |
| type | |
| ALT_DEFINITION | A substance that is being studied in the treatment of cancer. It belongs to the family of drugs called antitumor antibiotics.
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| Is_Value_For_GDC_Property | |
| subClassOf | |
| PDQ_Open_Trial_Search_ID | 269678
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| Accepted_Therapeutic_Use_For | non-Hodgkin's lyphoma
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| Semantic_Type | Pharmacologic Substance
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| Delete | Subject | Author | Type | Created |
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| No notes to display |