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Biological and Environmental Research Ontology
Last uploaded:
December 23, 2022
| Id | http://purl.obolibrary.org/obo/NCIT_C82386
http://purl.obolibrary.org/obo/NCIT_C82386
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|---|---|
| Preferred Name | Dabrafenib |
| Definitions |
An orally bioavailable inhibitor of B-raf (BRAF) protein with potential antineoplastic activity. Dabrafenib selectively binds to and inhibits the activity of B-raf, which may inhibit the proliferation of tumor cells which contain a mutated BRAF gene. B-raf belongs to the raf/mil family of serine/threonine protein kinases and plays a role in regulating the MAP kinase/ERKs signaling pathway, which may be constitutively activated due to BRAF gene mutations.
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| Type | http://www.w3.org/2002/07/owl#Class |
All Properties
| definition | An orally bioavailable inhibitor of B-raf (BRAF) protein with potential antineoplastic activity. Dabrafenib selectively binds to and inhibits the activity of B-raf, which may inhibit the proliferation of tumor cells which contain a mutated BRAF gene. B-raf belongs to the raf/mil family of serine/threonine protein kinases and plays a role in regulating the MAP kinase/ERKs signaling pathway, which may be constitutively activated due to BRAF gene mutations. |
|---|---|
| prefLabel | Dabrafenib
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| label | Dabrafenib
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| PDQ_Closed_Trial_Search_ID | 641977
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| code | C82386
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| prefixIRI | NCIT:C82386
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| in_subset |
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| Display_Name | Dabrafenib
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| Preferred_Name | Dabrafenib
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| FDA_UNII_Code | QGP4HA4G1B
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| Contributing_Source |
CTRP
FDA
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| Chemical_Formula | C23H20F3N5O2S2
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| Maps_To | Dabrafenib
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| CAS_Registry | 1195765-45-7
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| NCI_Drug_Dictionary_ID | 641977
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| Legacy Concept Name | BRAF_Inhibitor_GSK2118436
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| type | |
| Is_Value_For_GDC_Property | |
| subClassOf | |
| PDQ_Open_Trial_Search_ID | 641977
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| Accepted_Therapeutic_Use_For | metastatic non-small cell lung cancer (NSCLC) with BRAF V600E mutation
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| Semantic_Type | Pharmacologic Substance
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| UMLS_CUI | C3467876
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