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Biological and Environmental Research Ontology
Last uploaded:
December 23, 2022
| Id | http://purl.obolibrary.org/obo/NCIT_C82382
http://purl.obolibrary.org/obo/NCIT_C82382
|
|---|---|
| Preferred Name | Lurbinectedin |
| Definitions |
A synthetic tetrahydropyrrolo [4, 3, 2-de]quinolin-8(1H)-one alkaloid analogue with potential antineoplastic activity. Lurbinectedin covalently binds to residues lying in the minor groove of DNA, which may result in delayed progression through S phase, cell cycle arrest in the G2/M phase and cell death.
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| Type | http://www.w3.org/2002/07/owl#Class |
All Properties
| definition | A synthetic tetrahydropyrrolo [4, 3, 2-de]quinolin-8(1H)-one alkaloid analogue with potential antineoplastic activity. Lurbinectedin covalently binds to residues lying in the minor groove of DNA, which may result in delayed progression through S phase, cell cycle arrest in the G2/M phase and cell death. |
|---|---|
| prefLabel | Lurbinectedin
|
| label | Lurbinectedin
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| PDQ_Closed_Trial_Search_ID | 641468
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| code | C82382
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| Has_Target | |
| prefixIRI | NCIT:C82382
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| in_subset |
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| Display_Name | Lurbinectedin
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| Preferred_Name | Lurbinectedin
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| FDA_UNII_Code | 2CN60TN6ZS
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| Contributing_Source |
CTRP
FDA
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| Maps_To | Lurbinectedin
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| CAS_Registry | 497871-47-3
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| NCI_Drug_Dictionary_ID | 641468
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| Legacy Concept Name | DNA_Minor_Groove_Binding_Agent_PM01183
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| type | |
| Is_Value_For_GDC_Property | |
| subClassOf | |
| PDQ_Open_Trial_Search_ID | 641468
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| Accepted_Therapeutic_Use_For | adult patients with metastatic small cell lung cancer (SCLC) with disease progression on or after platinum-based chemotherapy
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| Semantic_Type |
Organic Chemical
Pharmacologic Substance
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| UMLS_CUI | C2830066
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