Biological and Environmental Research Ontology

Last uploaded: December 23, 2022
Id http://purl.obolibrary.org/obo/NCIT_C82358
http://purl.obolibrary.org/obo/NCIT_C82358
Preferred Name

Adecatumumab
Definitions
A recombinant human IgG1 monoclonal antibody (MoAb) directed against the tumor associated antigen (TAA) epithelial cell adhesion molecule (EpCAM) with potential antitumor activity. Adecatumumab binds to EpCAM, which may result in antibody-dependent cellular cytotoxicity (ADCC) directed against EpCAM-expressing tumor cells. EpCAM (CD326), a cell surface protein upregulated on many tumor cell types, promotes the proliferation, migration and invasiveness of tumor cells; for some cancers, overexpression has been correlated with decreased survival.
Type http://www.w3.org/2002/07/owl#Class

All Properties

definition

A recombinant human IgG1 monoclonal antibody (MoAb) directed against the tumor associated antigen (TAA) epithelial cell adhesion molecule (EpCAM) with potential antitumor activity. Adecatumumab binds to EpCAM, which may result in antibody-dependent cellular cytotoxicity (ADCC) directed against EpCAM-expressing tumor cells. EpCAM (CD326), a cell surface protein upregulated on many tumor cell types, promotes the proliferation, migration and invasiveness of tumor cells; for some cancers, overexpression has been correlated with decreased survival.
prefLabel
Adecatumumab
label
Adecatumumab
PDQ_Closed_Trial_Search_ID
640250
code
C82358
prefixIRI
NCIT:C82358
in_subset
Preferred_Name
Adecatumumab
FDA_UNII_Code
000705ZASD
Contributing_Source
FDA
Maps_To
Adecatumumab
CAS_Registry
503605-66-1
NCI_Drug_Dictionary_ID
640250
Legacy Concept Name
Adecatumumab
type
Is_Value_For_GDC_Property
subClassOf
PDQ_Open_Trial_Search_ID
640250
Semantic_Type
Pharmacologic Substance
UMLS_CUI
C1741817
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