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Biological and Environmental Research Ontology
Last uploaded:
December 23, 2022
| Id | http://purl.obolibrary.org/obo/NCIT_C82349
http://purl.obolibrary.org/obo/NCIT_C82349
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|---|---|
| Preferred Name | Aurora Kinase Inhibitor AMG 900 |
| Definitions |
A small-molecule inhibitor of Aurora kinases A, B and C with potential antineoplastic activity. Aurora kinase inhibitor AMG 900 selectively binds to and inhibits the activities of Aurora kinases A, B and C, which may result in inhibition of cellular division and proliferation in tumor cells that overexpress these kinases. Aurora kinases are serine-threonine kinases that play essential roles in mitotic checkpoint control during mitosis and are overexpressed by a wide variety of cancer cell types.
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| Type | http://www.w3.org/2002/07/owl#Class |
All Properties
| definition | A small-molecule inhibitor of Aurora kinases A, B and C with potential antineoplastic activity. Aurora kinase inhibitor AMG 900 selectively binds to and inhibits the activities of Aurora kinases A, B and C, which may result in inhibition of cellular division and proliferation in tumor cells that overexpress these kinases. Aurora kinases are serine-threonine kinases that play essential roles in mitotic checkpoint control during mitosis and are overexpressed by a wide variety of cancer cell types. |
|---|---|
| prefLabel | Aurora Kinase Inhibitor AMG 900
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| label | Aurora Kinase Inhibitor AMG 900
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| PDQ_Closed_Trial_Search_ID | 639524
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| code | C82349
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| Has_Target | |
| prefixIRI | NCIT:C82349
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| in_subset |
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| Display_Name | Aurora Kinase Inhibitor AMG 900
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| Preferred_Name | Aurora Kinase Inhibitor AMG 900
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| FDA_UNII_Code | 9R2G075611
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| Contributing_Source |
CTRP
FDA
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| Maps_To | Aurora Kinase Inhibitor AMG 900
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| CAS_Registry | 945595-80-2
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| NCI_Drug_Dictionary_ID | 639524
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| Legacy Concept Name | Aurora_Kinase_Inhibitor_AMG_900
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| type | |
| Is_Value_For_GDC_Property | |
| subClassOf | |
| PDQ_Open_Trial_Search_ID | 639524
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| Semantic_Type | Pharmacologic Substance
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| UMLS_CUI | C2830045
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