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Biological and Environmental Research Ontology
Last uploaded:
December 23, 2022
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| Preferred Name | Liraglutide | |
| Synonyms |
|
|
| Definitions |
A long-acting, fatty acylated glucagon-like peptide-1 (GLP-1) analog administered subcutaneously, with antihyperglycemic activity. Liraglutide's prolonged action and half-life of 11-15 hours are attributed to the attachment of the fatty acid palmitic acid to GLP-1 that reversibly binds to albumin. Albumin binding protects liraglutide from immediate degradation and elimination and causes GLP-1 to be released from abumin in a slow and consistent manner. This agent may cause thyroid C-cell tumors and increases the risk of acute pancreatitis. |
|
| ID |
http://purl.obolibrary.org/obo/NCIT_C82239 |
|
| CAS_Registry |
204656-20-2
|
|
| Chemical_Formula |
C172H265N43O51
|
|
| code |
C82239
|
|
| Contributing_Source |
CTRP FDA
|
|
| definition |
A long-acting, fatty acylated glucagon-like peptide-1 (GLP-1) analog administered subcutaneously, with antihyperglycemic activity. Liraglutide's prolonged action and half-life of 11-15 hours are attributed to the attachment of the fatty acid palmitic acid to GLP-1 that reversibly binds to albumin. Albumin binding protects liraglutide from immediate degradation and elimination and causes GLP-1 to be released from abumin in a slow and consistent manner. This agent may cause thyroid C-cell tumors and increases the risk of acute pancreatitis.
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|
| Display_Name |
Liraglutide
|
|
| FDA_UNII_Code |
839I73S42A
|
|
| in_subset |
http://purl.obolibrary.org/obo/NCIT_C63923 http://purl.obolibrary.org/obo/NCIT_C176424 |
|
| label |
Liraglutide
|
|
| Legacy Concept Name |
Liraglutide
|
|
| NCI_Drug_Dictionary_ID |
775374
|
|
| PDQ_Closed_Trial_Search_ID |
775374
|
|
| PDQ_Open_Trial_Search_ID |
775374
|
|
| Preferred_Name |
Liraglutide
|
|
| prefixIRI |
NCIT:C82239
|
|
| prefLabel |
Liraglutide
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|
| Semantic_Type |
Pharmacologic Substance
|
|
| UMLS_CUI |
C1456408
|
|
| subClassOf |
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