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Biological and Environmental Research Ontology
Last uploaded:
December 23, 2022
| Id | http://purl.obolibrary.org/obo/NCIT_C81423
http://purl.obolibrary.org/obo/NCIT_C81423
|
|---|---|
| Preferred Name | Nortopixantrone |
| Definitions |
A 9-aza-anthrapyrazole-based antineoplastic antibiotic. Nortopixantrone intercalates into DNA, induces single- and double-stranded DNA breaks and inhibits topoisomerase II, thereby inhibiting DNA replication and repair as well as RNA and protein synthesis. Nortopixantrone is less cardiotoxicity than anthracyclines.
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| Type | http://www.w3.org/2002/07/owl#Class |
All Properties
| definition | A 9-aza-anthrapyrazole-based antineoplastic antibiotic. Nortopixantrone intercalates into DNA, induces single- and double-stranded DNA breaks and inhibits topoisomerase II, thereby inhibiting DNA replication and repair as well as RNA and protein synthesis. Nortopixantrone is less cardiotoxicity than anthracyclines. |
|---|---|
| prefLabel | Nortopixantrone
|
| label | Nortopixantrone
|
| code | C81423
|
| prefixIRI | NCIT:C81423
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| in_subset | |
| Preferred_Name | Nortopixantrone
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| FDA_UNII_Code | PH2639TAB4
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| Contributing_Source | FDA
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| Chemical_Formula | C20H24N6O2
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| Maps_To | Nortopixantrone
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| CAS_Registry | 156090-17-4
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| Legacy Concept Name | Nortopixantrone
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| type | |
| Is_Value_For_GDC_Property | |
| subClassOf | |
| Semantic_Type | Pharmacologic Substance
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| UMLS_CUI | C2825625
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