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Biological and Environmental Research Ontology
Last uploaded:
December 23, 2022
| Id | http://purl.obolibrary.org/obo/NCIT_C80333
http://purl.obolibrary.org/obo/NCIT_C80333
|
|---|---|
| Preferred Name | Liarozole Hydrochloride |
| Definitions |
The fumarate salt of an orally-active benzimidazole derivative with potential antineoplastic activity. As a retinoic acid metabolism blocking agent (RAMBA), liarozole inhibits cytochrome P450-dependent all-trans-retinoic acid (ATRA)-4-hydroxylase, resulting in an increase in endogenous ATRA production, inhibition of cell proliferation, and induction of cell differentiation. This agent also inhibits aromatase, the enzyme that catalyzes the final, rate-limiting step in estrogen biosynthesis.
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| Type | http://www.w3.org/2002/07/owl#Class |
All Properties
| definition | The fumarate salt of an orally-active benzimidazole derivative with potential antineoplastic activity. As a retinoic acid metabolism blocking agent (RAMBA), liarozole inhibits cytochrome P450-dependent all-trans-retinoic acid (ATRA)-4-hydroxylase, resulting in an increase in endogenous ATRA production, inhibition of cell proliferation, and induction of cell differentiation. This agent also inhibits aromatase, the enzyme that catalyzes the final, rate-limiting step in estrogen biosynthesis. |
|---|---|
| prefLabel | Liarozole Hydrochloride
|
| label | Liarozole Hydrochloride
|
| code | C80333
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| prefixIRI | NCIT:C80333
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| in_subset | |
| Preferred_Name | Liarozole Hydrochloride
|
| FDA_UNII_Code | 29T7S2IB97
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| Contributing_Source | FDA
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| Chemical_Formula | C17H13ClN4.HCl
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| Maps_To | Liarozole Hydrochloride
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| CAS_Registry | 145858-50-0
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| Legacy Concept Name | Liarozole_Hydrochloride
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| Has_Free_Acid_Or_Base_Form | |
| type | |
| Is_Value_For_GDC_Property | |
| subClassOf | |
| Semantic_Type |
Organic Chemical
Pharmacologic Substance
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| UMLS_CUI | C2697919
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