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Biological and Environmental Research Ontology
Last uploaded:
December 23, 2022
| Id | http://purl.obolibrary.org/obo/NCIT_C80327
http://purl.obolibrary.org/obo/NCIT_C80327
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|---|---|
| Preferred Name | Safingol Hydrochloride |
| Definitions |
The hydrochloride salt of a saturated derivative of sphingosine. As an inhibitor of protein kinase C (PKC), safingol competitively binds to the regulatory phorbol-binding domain of PKC, a kinase involved in tumorigenesis. This agent has been shown to act synergistically with other chemotherapeutic agents and may potentiate chemotherapy drug-induced apoptosis in vitro and in vivo.
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| Type | http://www.w3.org/2002/07/owl#Class |
All Properties
| definition | The hydrochloride salt of a saturated derivative of sphingosine. As an inhibitor of protein kinase C (PKC), safingol competitively binds to the regulatory phorbol-binding domain of PKC, a kinase involved in tumorigenesis. This agent has been shown to act synergistically with other chemotherapeutic agents and may potentiate chemotherapy drug-induced apoptosis in vitro and in vivo. |
|---|---|
| prefLabel | Safingol Hydrochloride
|
| label | Safingol Hydrochloride
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| code | C80327
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| prefixIRI | NCIT:C80327
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| in_subset | |
| Preferred_Name | Safingol Hydrochloride
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| FDA_UNII_Code | 30MA50WJ4N
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| Contributing_Source | FDA
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| Chemical_Formula | C18H39NO2.HCl
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| CAS_Registry | 139755-79-6
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| Legacy Concept Name | Safingol_Hydrochloride
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| Has_Free_Acid_Or_Base_Form | |
| type | |
| subClassOf | |
| Semantic_Type |
Organic Chemical
Pharmacologic Substance
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| UMLS_CUI | C0888599
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