Biological and Environmental Research Ontology

Last uploaded: December 23, 2022
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Preferred Name

Zoledronic Acid Anhydrous
Synonyms
Definitions

Anhydrous form of a synthetic imidazole third generation bisphosphonate analog of pyrophosphate with antiresorptive activity. Zoledronate binds to hydroxyapatite crystals in the bone matrix and inhibits farnesyl pyrophosphate (diphosphate) synthase, thereby preventing protein prenylation within the mevalonate pathway. This leads to the loss of downstream metabolites essential for osteoclast function, leading to the induction of apoptosis and eventually, osteoclast-cell death. By preventing osteoclast-mediated bone resorption, zoledronate decreases bone turnover and stabilizes the bone matrix.
ID

http://purl.obolibrary.org/obo/NCIT_C80120
CAS_Registry

118072-93-8
CHEBI_ID

CHEBI:46557
Chemical_Formula

C5H10N2O7P2
code

C80120
Contributing_Source

FDA
definition

Anhydrous form of a synthetic imidazole third generation bisphosphonate analog of pyrophosphate with antiresorptive activity. Zoledronate binds to hydroxyapatite crystals in the bone matrix and inhibits farnesyl pyrophosphate (diphosphate) synthase, thereby preventing protein prenylation within the mevalonate pathway. This leads to the loss of downstream metabolites essential for osteoclast function, leading to the induction of apoptosis and eventually, osteoclast-cell death. By preventing osteoclast-mediated bone resorption, zoledronate decreases bone turnover and stabilizes the bone matrix.
FDA_UNII_Code

70HZ18PH24
in_subset

http://purl.obolibrary.org/obo/NCIT_C63923
label

Zoledronic Acid Anhydrous
Legacy Concept Name

Zolendronic_Acid_Anhydrous
Preferred_Name

Zoledronic Acid Anhydrous
prefixIRI

NCIT:C80120
prefLabel

Zoledronic Acid Anhydrous
Semantic_Type

Pharmacologic Substance
UMLS_CUI

C2700334
subClassOf

http://purl.obolibrary.org/obo/NCIT_C443
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