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Biological and Environmental Research Ontology
Last uploaded:
December 23, 2022
| Id | http://purl.obolibrary.org/obo/NCIT_C80066
http://purl.obolibrary.org/obo/NCIT_C80066
|
|---|---|
| Preferred Name | Trabedersen |
| Definitions |
A transforming growth factor (TGF)-beta2 specific phosphorothioate antisense oligodeoxynucleotide with the sequence 5'-CGGCATGTCTATTTTGTA-3', with potential antineoplastic activity. Trebedersen binds to TGF-beta2 mRNA causing inhibition of protein translation, thereby decreasing TGF-beta2 protein levels; decreasing intratumoral TGF-beta2 levels may result in the inhibition of tumor cell growth and migration, and tumor angiogenesis. TGF-beta2, a cytokine often over-expressed in various malignancies, may play an important role in promoting the growth, progression, and migration of tumor cells.
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| Type | http://www.w3.org/2002/07/owl#Class |
All Properties
| definition | A transforming growth factor (TGF)-beta2 specific phosphorothioate antisense oligodeoxynucleotide with the sequence 5'-CGGCATGTCTATTTTGTA-3', with potential antineoplastic activity. Trebedersen binds to TGF-beta2 mRNA causing inhibition of protein translation, thereby decreasing TGF-beta2 protein levels; decreasing intratumoral TGF-beta2 levels may result in the inhibition of tumor cell growth and migration, and tumor angiogenesis. TGF-beta2, a cytokine often over-expressed in various malignancies, may play an important role in promoting the growth, progression, and migration of tumor cells. |
|---|---|
| prefLabel | Trabedersen
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| label | Trabedersen
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| PDQ_Closed_Trial_Search_ID | 617455
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| code | C80066
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| Has_Target | |
| prefixIRI | NCIT:C80066
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| in_subset |
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| Display_Name | Trabedersen
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| Preferred_Name | Trabedersen
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| FDA_UNII_Code | 98OYR854NY
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| Contributing_Source |
CTRP
FDA
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| Maps_To | Trabedersen
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| CAS_Registry | 925681-61-4
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| NCI_Drug_Dictionary_ID | 617455
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| Legacy Concept Name | Trabedersen
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| type | |
| Is_Value_For_GDC_Property | |
| subClassOf | |
| PDQ_Open_Trial_Search_ID | 617455
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| Semantic_Type |
Pharmacologic Substance
Nucleic Acid, Nucleoside, or Nucleotide
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| UMLS_CUI | C2699985
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