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Biological and Environmental Research Ontology
Last uploaded:
December 23, 2022
| Id | http://purl.obolibrary.org/obo/NCIT_C80059
http://purl.obolibrary.org/obo/NCIT_C80059
|
|---|---|
| Preferred Name | Niraparib |
| Definitions |
An orally bioavailable inhibitor of poly (ADP-ribose) polymerase (PARP) types 1 and 2 (PARP-1 and -2), with antineoplastic activity. Upon administration, niraparib binds to and inhibits the activity of PARP-1 and -2, thereby inhibiting PARP-1 and -2-mediated DNA repair, enhancing the accumulation of DNA strand breaks, promoting genomic instability and resulting in apoptosis. The PARP family of proteins catalyzes post-translational ADP-ribosylation of nuclear proteins and is activated by single-strand DNA (ssDNA) breaks.
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| Type | http://www.w3.org/2002/07/owl#Class |
All Properties
| definition | An orally bioavailable inhibitor of poly (ADP-ribose) polymerase (PARP) types 1 and 2 (PARP-1 and -2), with antineoplastic activity. Upon administration, niraparib binds to and inhibits the activity of PARP-1 and -2, thereby inhibiting PARP-1 and -2-mediated DNA repair, enhancing the accumulation of DNA strand breaks, promoting genomic instability and resulting in apoptosis. The PARP family of proteins catalyzes post-translational ADP-ribosylation of nuclear proteins and is activated by single-strand DNA (ssDNA) breaks. |
|---|---|
| prefLabel | Niraparib
|
| label | Niraparib
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| Has_Salt_Form | |
| PDQ_Closed_Trial_Search_ID | 615263
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| code | C80059
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| Has_Target | |
| prefixIRI | NCIT:C80059
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| in_subset |
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| Display_Name | Niraparib
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| Preferred_Name | Niraparib
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| FDA_UNII_Code | HMC2H89N35
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| Contributing_Source |
CTRP
FDA
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| Maps_To | Niraparib
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| CAS_Registry | 1038915-60-4
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| NCI_Drug_Dictionary_ID | 615263
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| Legacy Concept Name | PARP_Inhibitor_MK4827
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| type | |
| Is_Value_For_GDC_Property | |
| subClassOf | |
| PDQ_Open_Trial_Search_ID | 615263
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| Semantic_Type | Pharmacologic Substance
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| UMLS_CUI | C2744440
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