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Biological and Environmental Research Ontology
Last uploaded:
December 23, 2022
| Id | http://purl.obolibrary.org/obo/NCIT_C80056
http://purl.obolibrary.org/obo/NCIT_C80056
|
|---|---|
| Preferred Name | Ioflubenzamide I-131 |
| Definitions |
An iodine 131-radiolabeled small-molecule benzamide compound with potential antineoplastic activity. The benzamide moiety of 131-I-MIP-1145 binds to melanin, selectively delivering a cyotoxic dose of gamma and beta radiation to melanin-expressing tumor cells. Melanin pigments, polymer derivatives of the amino acid tyrosine, are over-expressed in approximately 40% of melanomas.
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| Type | http://www.w3.org/2002/07/owl#Class |
All Properties
| definition | An iodine 131-radiolabeled small-molecule benzamide compound with potential antineoplastic activity. The benzamide moiety of 131-I-MIP-1145 binds to melanin, selectively delivering a cyotoxic dose of gamma and beta radiation to melanin-expressing tumor cells. Melanin pigments, polymer derivatives of the amino acid tyrosine, are over-expressed in approximately 40% of melanomas. |
|---|---|
| prefLabel | Ioflubenzamide I-131
|
| label | Ioflubenzamide I-131
|
| PDQ_Closed_Trial_Search_ID | 615097
|
| code | C80056
|
| prefixIRI | NCIT:C80056
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| in_subset | |
| Preferred_Name | Ioflubenzamide I-131
|
| FDA_UNII_Code | 65O1D58Z6V
|
| Contributing_Source | FDA
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| Chemical_Formula | C21H25FIN3O3
|
| Maps_To | Ioflubenzamide I-131
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| CAS_Registry | 1214283-52-9
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| NCI_Drug_Dictionary_ID | 615097
|
| Legacy Concept Name | Iodine_I_131_MIP-1145
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| type | |
| Is_Value_For_GDC_Property | |
| subClassOf | |
| PDQ_Open_Trial_Search_ID | 615097
|
| Semantic_Type | Pharmacologic Substance
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| UMLS_CUI | C2934646
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| Delete | Subject | Author | Type | Created |
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