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Biological and Environmental Research Ontology
Last uploaded:
December 23, 2022
| Id | http://purl.obolibrary.org/obo/NCIT_C80050
http://purl.obolibrary.org/obo/NCIT_C80050
|
|---|---|
| Preferred Name | Copper Gluconate |
| Definitions |
The orally bioavailable copper salt of D-gluconic acid. In addition to its roles as an enzyme cofactor for cytochrome C oxidase and superoxide dismutase, copper forms complexes with the thiocarbamate disulfiram (DSF) forming DSF-copper complexes, which enhances the DSF-mediated inhibition of the 26S proteasome; proteasome inhibition may result in inhibition of cellular protein degradation, cessation of cell cycle progression, inhibition of cellular proliferation, and the induction of apoptosis in susceptible tumor cell populations.
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| Type | http://www.w3.org/2002/07/owl#Class |
All Properties
| definition | The orally bioavailable copper salt of D-gluconic acid. In addition to its roles as an enzyme cofactor for cytochrome C oxidase and superoxide dismutase, copper forms complexes with the thiocarbamate disulfiram (DSF) forming DSF-copper complexes, which enhances the DSF-mediated inhibition of the 26S proteasome; proteasome inhibition may result in inhibition of cellular protein degradation, cessation of cell cycle progression, inhibition of cellular proliferation, and the induction of apoptosis in susceptible tumor cell populations. |
|---|---|
| prefLabel | Copper Gluconate
|
| label | Copper Gluconate
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| PDQ_Closed_Trial_Search_ID | 614606
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| code | C80050
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| Has_Target | |
| prefixIRI | NCIT:C80050
|
| in_subset |
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| Display_Name | Copper Gluconate
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| Preferred_Name | Copper Gluconate
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| FDA_UNII_Code | RV823G6G67
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| Contributing_Source |
CTRP
FDA
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| Chemical_Formula | 2C6H11O7.Cu
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| Maps_To | Copper Gluconate
|
| CAS_Registry | 527-09-3
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| NCI_Drug_Dictionary_ID | 614606
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| Legacy Concept Name | Copper_Gluconate
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| type | |
| Is_Value_For_GDC_Property | |
| subClassOf | |
| PDQ_Open_Trial_Search_ID | 614606
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| Semantic_Type | Pharmacologic Substance
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| UMLS_CUI | C0982097
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