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Biological and Environmental Research Ontology
Last uploaded:
December 23, 2022
| Id | http://purl.obolibrary.org/obo/NCIT_C80047
http://purl.obolibrary.org/obo/NCIT_C80047
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|---|---|
| Preferred Name | Camptothecin Analogue TLC388 |
| Definitions |
A synthetic analogue of camptothecin with potential antineoplastic and radio-sensitizing activities. Camptothecin analogue TLC388 selectively stabilizes topoisomerase I-DNA covalent complexes during S-phase, thereby inhibiting religation of topoisomerase I-mediated single-strand DNA breaks and producing potentially lethal double-strand DNA breaks when encountered by the DNA replication machinery. Topoisomerase I relaxes negative super-coiled DNA during replication and transcription. This agent has been chemically modified to enhance the potency and stability of camptothecin.
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| Type | http://www.w3.org/2002/07/owl#Class |
All Properties
| definition | A synthetic analogue of camptothecin with potential antineoplastic and radio-sensitizing activities. Camptothecin analogue TLC388 selectively stabilizes topoisomerase I-DNA covalent complexes during S-phase, thereby inhibiting religation of topoisomerase I-mediated single-strand DNA breaks and producing potentially lethal double-strand DNA breaks when encountered by the DNA replication machinery. Topoisomerase I relaxes negative super-coiled DNA during replication and transcription. This agent has been chemically modified to enhance the potency and stability of camptothecin. |
|---|---|
| prefLabel | Camptothecin Analogue TLC388
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| label | Camptothecin Analogue TLC388
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| PDQ_Closed_Trial_Search_ID | 615096
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| code | C80047
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| prefixIRI | NCIT:C80047
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| in_subset |
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| Display_Name | Camptothecin Analogue TLC388
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| Preferred_Name | Camptothecin Analogue TLC388
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| FDA_UNII_Code | D47234N30N
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| Contributing_Source |
CTRP
FDA
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| Maps_To | Camptothecin Analogue TLC388
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| CAS_Registry | 1432468-79-5
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| NCI_Drug_Dictionary_ID | 615096
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| Legacy Concept Name | Camptothecin_Analogue_TLC388
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| type | |
| Is_Value_For_GDC_Property | |
| subClassOf | |
| PDQ_Open_Trial_Search_ID | 615096
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| Semantic_Type |
Organic Chemical
Pharmacologic Substance
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| UMLS_CUI | C2703206
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