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Biological and Environmental Research Ontology
Last uploaded:
December 23, 2022
| Id | http://purl.obolibrary.org/obo/NCIT_C80040
http://purl.obolibrary.org/obo/NCIT_C80040
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|---|---|
| Preferred Name | Anti-DKK1 Monoclonal Antibody BHQ880 |
| Definitions |
A humanized monoclonal antibody directed against Wnt antagonist Dickkopf-1 (DKK1) with potential anti-osteolytic activity. Anti-DKK1 monoclonal antibody BHQ880 binds to and inhibits DKK1, enhancing signaling through the Wnt pathway, which may result in osteoblast differentiation and activation within the bone matrix and the reversal of tumor-induced osteolytic disease. DKK1 is a potent Wnt signaling pathway antagonist.
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| Type | http://www.w3.org/2002/07/owl#Class |
All Properties
| definition | A humanized monoclonal antibody directed against Wnt antagonist Dickkopf-1 (DKK1) with potential anti-osteolytic activity. Anti-DKK1 monoclonal antibody BHQ880 binds to and inhibits DKK1, enhancing signaling through the Wnt pathway, which may result in osteoblast differentiation and activation within the bone matrix and the reversal of tumor-induced osteolytic disease. DKK1 is a potent Wnt signaling pathway antagonist. |
|---|---|
| label | Anti-DKK1 Monoclonal Antibody BHQ880
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| prefLabel | Anti-DKK1 Monoclonal Antibody BHQ880
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| Legacy Concept Name | Anti-DKK1_Monoclonal_Antibody_BHQ880
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| in_subset |
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| Preferred_Name | Anti-DKK1 Monoclonal Antibody BHQ880
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| Is_Value_For_GDC_Property | |
| Display_Name | Anti-DKK1 Monoclonal Antibody BHQ880
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| Maps_To | Anti-DKK1 Monoclonal Antibody BHQ880
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| PDQ_Open_Trial_Search_ID | 614254
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| Has_Target | |
| UMLS_CUI | C2703201
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| FDA_UNII_Code | IS3ESI44W5
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| prefixIRI | NCIT:C80040
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| NCI_Drug_Dictionary_ID | 614254
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| Contributing_Source |
CTRP
FDA
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| subClassOf | |
| code | C80040
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| type | |
| PDQ_Closed_Trial_Search_ID | 614254
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| Semantic_Type |
Amino Acid, Peptide, or Protein
Pharmacologic Substance
Immunologic Factor
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| Delete | Subject | Author | Type | Created |
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