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Biological and Environmental Research Ontology
Last uploaded:
December 23, 2022
| Id | http://purl.obolibrary.org/obo/NCIT_C79827
http://purl.obolibrary.org/obo/NCIT_C79827
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|---|---|
| Preferred Name | Irosustat |
| Definitions |
Steroid sulfatase inhibitor BN 83495 selectively binds to and inhibits steroid sulfatase (STS), which may inhibit the production of locally active estrogens and so inhibit estrogen-dependent cell growth in tumor cells, such as those of the breast, ovary, and endometrium. STS is a cytoplasmic enzyme responsible for the conversion of circulating inactive estrone sulfate and estradiol sulfate to biologically active unconjugated estrone and estradiol, respectively.
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| Type | http://www.w3.org/2002/07/owl#Class |
All Properties
| definition | Steroid sulfatase inhibitor BN 83495 selectively binds to and inhibits steroid sulfatase (STS), which may inhibit the production of locally active estrogens and so inhibit estrogen-dependent cell growth in tumor cells, such as those of the breast, ovary, and endometrium. STS is a cytoplasmic enzyme responsible for the conversion of circulating inactive estrone sulfate and estradiol sulfate to biologically active unconjugated estrone and estradiol, respectively. |
|---|---|
| prefLabel | Irosustat
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| label | Irosustat
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| PDQ_Closed_Trial_Search_ID | 626715
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| code | C79827
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| Has_Target | |
| prefixIRI | NCIT:C79827
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| in_subset |
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| Display_Name | Irosustat
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| Preferred_Name | Irosustat
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| FDA_UNII_Code | 366037O6O7
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| Contributing_Source |
CTRP
FDA
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| Chemical_Formula | C14H15NO5S
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| Maps_To | Irosustat
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| CAS_Registry | 288628-05-7
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| NCI_Drug_Dictionary_ID | 626715
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| Legacy Concept Name | Steroid_Sulfatase_Inhibitor_BN_83495
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| type | |
| Is_Value_For_GDC_Property | |
| subClassOf | |
| PDQ_Open_Trial_Search_ID | 626715
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| Semantic_Type | Pharmacologic Substance
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| UMLS_CUI | C3853843
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| Delete | Subject | Author | Type | Created |
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