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Biological and Environmental Research Ontology
Last uploaded:
December 23, 2022
| Id | http://purl.obolibrary.org/obo/NCIT_C794
http://purl.obolibrary.org/obo/NCIT_C794
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|---|---|
| Preferred Name | Quinine |
| Definitions |
A quinidine alkaloid isolated from the bark of the cinchona tree. Quinine has many mechanisms of action, including reduction of oxygen intake and carbohydrate metabolism; disruption of DNA replication and transcription via DNA intercalation; and reduction of the excitability of muscle fibers via alteration of calcium distribution. This agent also inhibits the drug efflux pump P-glycoprotein which is overexpressed in multi-drug resistant tumors and may improve the efficacy of some antineoplastic agents. (NCI04)
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| Type | http://www.w3.org/2002/07/owl#Class |
All Properties
| definition | A quinidine alkaloid isolated from the bark of the cinchona tree. Quinine has many mechanisms of action, including reduction of oxygen intake and carbohydrate metabolism; disruption of DNA replication and transcription via DNA intercalation; and reduction of the excitability of muscle fibers via alteration of calcium distribution. This agent also inhibits the drug efflux pump P-glycoprotein which is overexpressed in multi-drug resistant tumors and may improve the efficacy of some antineoplastic agents. (NCI04) |
|---|---|
| prefLabel | Quinine
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| label | Quinine
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| Has_Salt_Form | |
| CHEBI_ID | CHEBI:15854
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| PDQ_Closed_Trial_Search_ID | 41253
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| code | C794
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| prefixIRI | NCIT:C794
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| in_subset | |
| Preferred_Name | Quinine
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| FDA_UNII_Code | A7V27PHC7A
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| Contributing_Source | FDA
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| Chemical_Formula | C20H24N2O2
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| Maps_To | Quinine
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| CAS_Registry | 130-95-0
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| NSC Number | 192949
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| NCI_Drug_Dictionary_ID | 41253
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| Legacy Concept Name | Quinine
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| type | |
| Is_Value_For_GDC_Property | |
| subClassOf | |
| PDQ_Open_Trial_Search_ID | 41253
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| Semantic_Type |
Organic Chemical
Pharmacologic Substance
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| UMLS_CUI | C0034417
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| Delete | Subject | Author | Type | Created |
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