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Biological and Environmental Research Ontology
Last uploaded:
December 23, 2022
| Id | http://purl.obolibrary.org/obo/NCIT_C78848
http://purl.obolibrary.org/obo/NCIT_C78848
|
|---|---|
| Preferred Name | Sonolisib |
| Definitions |
A small-molecule wortmannin analogue inhibitor of the alpha, gamma, and delta isoforms of phosphoinositide 3-kinase (PI3K) with potential antineoplastic activity. Sonolisib inhibits the production of the secondary messenger phosphatidylinositol-3,4,5-trisphosphate (PIP3) and activation of the PI3K/Akt signaling pathway, which may result in inhibition of tumor cell growth and survival in susceptible tumor cell populations. Activation of the PI3K/Akt signaling pathway is frequently associated with tumorigenesis and dysregulated PI3K/Akt signaling may contribute to tumor resistance to a variety of antineoplastic agents.
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| Type | http://www.w3.org/2002/07/owl#Class |
All Properties
| definition | A small-molecule wortmannin analogue inhibitor of the alpha, gamma, and delta isoforms of phosphoinositide 3-kinase (PI3K) with potential antineoplastic activity. Sonolisib inhibits the production of the secondary messenger phosphatidylinositol-3,4,5-trisphosphate (PIP3) and activation of the PI3K/Akt signaling pathway, which may result in inhibition of tumor cell growth and survival in susceptible tumor cell populations. Activation of the PI3K/Akt signaling pathway is frequently associated with tumorigenesis and dysregulated PI3K/Akt signaling may contribute to tumor resistance to a variety of antineoplastic agents. |
|---|---|
| prefLabel | Sonolisib
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| label | Sonolisib
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| PDQ_Closed_Trial_Search_ID | 612038
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| code | C78848
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| Has_Target | |
| prefixIRI | NCIT:C78848
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| in_subset |
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| Display_Name | Sonolisib
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| Preferred_Name | Sonolisib
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| FDA_UNII_Code | 987796874T
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| Contributing_Source |
CTRP
FDA
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| Maps_To | Sonolisib
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| CAS_Registry | 502632-66-8
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| NCI_Drug_Dictionary_ID | 612038
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| Legacy Concept Name | PI3K_Inhibitor_PX-866
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| type | |
| Is_Value_For_GDC_Property | |
| subClassOf | |
| PDQ_Open_Trial_Search_ID | 612038
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| Semantic_Type | Pharmacologic Substance
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| UMLS_CUI | C1566038
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