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Biological and Environmental Research Ontology
Last uploaded:
December 23, 2022
| Id | http://purl.obolibrary.org/obo/NCIT_C78831
http://purl.obolibrary.org/obo/NCIT_C78831
|
|---|---|
| Preferred Name | Androstane Steroid HE3235 |
| Definitions |
An orally bioavailable adrenal steroid analogue with potential antineoplastic activity. Androstane steroid HE3235 appears to bind the androgen receptor (AR), down-regulating anti-apoptotic genes, such as Bcl-2, while increasing the expression of pro-apoptotic genes, such as caspases. In vitro and in vivo studies indicate that this agent inhibits androstenediol-dependent LNCaP cell tumor growth. In addition, HE3235 may potentiate chemotherapeutic agents by down-regulating ABCG2, the gene encoding the multi-drug resistant (MDR) protein MDR2.
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| Type | http://www.w3.org/2002/07/owl#Class |
All Properties
| definition | An orally bioavailable adrenal steroid analogue with potential antineoplastic activity. Androstane steroid HE3235 appears to bind the androgen receptor (AR), down-regulating anti-apoptotic genes, such as Bcl-2, while increasing the expression of pro-apoptotic genes, such as caspases. In vitro and in vivo studies indicate that this agent inhibits androstenediol-dependent LNCaP cell tumor growth. In addition, HE3235 may potentiate chemotherapeutic agents by down-regulating ABCG2, the gene encoding the multi-drug resistant (MDR) protein MDR2. |
|---|---|
| prefLabel | Androstane Steroid HE3235
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| label | Androstane Steroid HE3235
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| PDQ_Closed_Trial_Search_ID | 601983
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| code | C78831
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| prefixIRI | NCIT:C78831
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| in_subset |
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| Display_Name | Androstane Steroid HE3235
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| Preferred_Name | Androstane Steroid HE3235
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| FDA_UNII_Code | 891O182ZP5
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| Contributing_Source |
CTRP
FDA
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| Maps_To | Androstane Steroid HE3235
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| CAS_Registry | 183387-50-0
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| NCI_Drug_Dictionary_ID | 601983
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| Legacy Concept Name | Adrenal_Steroid_Analogue_HE3235
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| type | |
| Is_Value_For_GDC_Property | |
| subClassOf | |
| PDQ_Open_Trial_Search_ID | 601983
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| Semantic_Type | Pharmacologic Substance
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| UMLS_CUI | C2715313
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