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Biological and Environmental Research Ontology
Last uploaded:
December 23, 2022
| Id | http://purl.obolibrary.org/obo/NCIT_C78532
http://purl.obolibrary.org/obo/NCIT_C78532
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|---|---|
| Preferred Name | Pseudomonas Exotoxin Immunoconjugate |
| Definitions |
An immunotoxin containing epitope of Pseudomonas exotoxin (PE) with immunotherapeutic property. PE, a peptide toxin of 613 amino acids, consists of 3 functional domains: an amino-terminal receptor-binding domain, a middle translocation domain, and a carboxyl-terminal ADP-ribosylation domain. The last 5 carboxyl-terminal amino acids, Arg-Glu-Asp-Leu-Lys, are critical for its cytotoxic action.
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| Type | http://www.w3.org/2002/07/owl#Class |
All Properties
| definition | An immunotoxin containing epitope of Pseudomonas exotoxin (PE) with immunotherapeutic property. PE, a peptide toxin of 613 amino acids, consists of 3 functional domains: an amino-terminal receptor-binding domain, a middle translocation domain, and a carboxyl-terminal ADP-ribosylation domain. The last 5 carboxyl-terminal amino acids, Arg-Glu-Asp-Leu-Lys, are critical for its cytotoxic action. |
|---|---|
| prefLabel | Pseudomonas Exotoxin Immunoconjugate
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| label | Pseudomonas Exotoxin Immunoconjugate
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| code | C78532
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| prefixIRI | NCIT:C78532
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| Preferred_Name | Pseudomonas Exotoxin Immunoconjugate
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| Legacy Concept Name | Pseudomonas_Exotoxin_Immunoconjugate
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| type | |
| subClassOf | |
| Semantic_Type | Pharmacologic Substance
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| UMLS_CUI | C2698914
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