Biological and Environmental Research Ontology

Last uploaded: December 23, 2022
Id http://purl.obolibrary.org/obo/NCIT_C78484
http://purl.obolibrary.org/obo/NCIT_C78484
Preferred Name

IAP Inhibitor HGS1029
Definitions
The hydrochloride salt of a small-molecule inhibitor of IAP (Inhibitor of Apoptosis Protein) family proteins with potential antineoplastic activity. IAP inhibitor HGS1029 selectively inhibits the biological activity of IAP proteins, which may restore apoptotic signaling pathways; this agent may work synergistically with cytotoxic drugs to overcome tumor cell resistance to apoptosis. IAPs are overexpressed by many cancer cell types, suppressing apoptosis by binding and inhibiting active caspases-3, -7 and -9 via their BIR (baculoviral lAP repeat) domains.
Type http://www.w3.org/2002/07/owl#Class

All Properties

definition

The hydrochloride salt of a small-molecule inhibitor of IAP (Inhibitor of Apoptosis Protein) family proteins with potential antineoplastic activity. IAP inhibitor HGS1029 selectively inhibits the biological activity of IAP proteins, which may restore apoptotic signaling pathways; this agent may work synergistically with cytotoxic drugs to overcome tumor cell resistance to apoptosis. IAPs are overexpressed by many cancer cell types, suppressing apoptosis by binding and inhibiting active caspases-3, -7 and -9 via their BIR (baculoviral lAP repeat) domains.
prefLabel
IAP Inhibitor HGS1029
label
IAP Inhibitor HGS1029
NCI_META_CUI
CL387473
PDQ_Closed_Trial_Search_ID
601033
code
C78484
Has_Target
prefixIRI
NCIT:C78484
in_subset
Display_Name
IAP Inhibitor HGS1029
Preferred_Name
IAP Inhibitor HGS1029
Contributing_Source
CTRP
Maps_To
IAP Inhibitor HGS1029
NCI_Drug_Dictionary_ID
601033
Legacy Concept Name
IAP_Inhibitor_HGS1029
type
Is_Value_For_GDC_Property
subClassOf
PDQ_Open_Trial_Search_ID
601033
Semantic_Type
Organic Chemical
Pharmacologic Substance
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