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Biological and Environmental Research Ontology
Last uploaded:
December 23, 2022
| Id | http://purl.obolibrary.org/obo/NCIT_C78476
http://purl.obolibrary.org/obo/NCIT_C78476
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|---|---|
| Preferred Name | mTOR Kinase Inhibitor OSI-027 |
| Definitions |
An orally bioavailable mammalian target of rapamycin (mTOR) kinase inhibitor with potential antineoplastic activity. mTOR kinase inhibitor OSI-027 binds to and inhibits both the raptor-mTOR (TOR complex 1 or TORC1) and the rictor-mTOR (TOR complex 2 or TORC2) complexes of mTOR, which may result in tumor cell apoptosis and a decrease in tumor cell proliferation. mTOR is a serine/threonine kinase that is upregulated in some tumors and plays an important role downstream in the PI3K/Akt/mTOR signaling pathway.
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| Type | http://www.w3.org/2002/07/owl#Class |
All Properties
| definition | An orally bioavailable mammalian target of rapamycin (mTOR) kinase inhibitor with potential antineoplastic activity. mTOR kinase inhibitor OSI-027 binds to and inhibits both the raptor-mTOR (TOR complex 1 or TORC1) and the rictor-mTOR (TOR complex 2 or TORC2) complexes of mTOR, which may result in tumor cell apoptosis and a decrease in tumor cell proliferation. mTOR is a serine/threonine kinase that is upregulated in some tumors and plays an important role downstream in the PI3K/Akt/mTOR signaling pathway. |
|---|---|
| prefLabel | mTOR Kinase Inhibitor OSI-027
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| label | mTOR Kinase Inhibitor OSI-027
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| PDQ_Closed_Trial_Search_ID | 600513
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| code | C78476
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| prefixIRI | NCIT:C78476
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| in_subset |
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| Display_Name | mTOR Kinase Inhibitor OSI-027
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| Preferred_Name | mTOR Kinase Inhibitor OSI-027
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| FDA_UNII_Code | 25MKH1SZ0M
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| Contributing_Source |
CTRP
FDA
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| Maps_To | mTOR Kinase Inhibitor OSI-027
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| CAS_Registry | 936890-98-1
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| NCI_Drug_Dictionary_ID | 600513
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| Legacy Concept Name | mTOR_Kinase_Inhibitor_OSI-027
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| type | |
| Is_Value_For_GDC_Property | |
| subClassOf | |
| PDQ_Open_Trial_Search_ID | 600513
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| Semantic_Type |
Organic Chemical
Pharmacologic Substance
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| UMLS_CUI | C2703121
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