Biological and Environmental Research Ontology

Last uploaded: December 23, 2022
Id http://purl.obolibrary.org/obo/NCIT_C78470
http://purl.obolibrary.org/obo/NCIT_C78470
Preferred Name

PI3K Inhibitor GSK1059615
Definitions
A phosphoinositide 3-kinase (PI3K) inhibitor with potential antineoplastic activity. PI3K inhibitor GSK1059615 inhibits PI3K in the PI3K/AKT kinase signaling pathway, which may trigger the translocation of cytosolic Bax to the mitochondrial outer membrane and an increase in mitochondrial membrane permeability, followed by apoptosis. Bax is a member of the proapoptotic Bcl-2 family of proteins. PI3K, an enzyme often overexpressed in cancer cells, plays a crucial role in tumor cell regulation and survival.
Type http://www.w3.org/2002/07/owl#Class

All Properties

definition

A phosphoinositide 3-kinase (PI3K) inhibitor with potential antineoplastic activity. PI3K inhibitor GSK1059615 inhibits PI3K in the PI3K/AKT kinase signaling pathway, which may trigger the translocation of cytosolic Bax to the mitochondrial outer membrane and an increase in mitochondrial membrane permeability, followed by apoptosis. Bax is a member of the proapoptotic Bcl-2 family of proteins. PI3K, an enzyme often overexpressed in cancer cells, plays a crucial role in tumor cell regulation and survival.
prefLabel
PI3K Inhibitor GSK1059615
label
PI3K Inhibitor GSK1059615
NCI_META_CUI
CL387567
PDQ_Closed_Trial_Search_ID
600076
code
C78470
Has_Target
prefixIRI
NCIT:C78470
in_subset
Display_Name
PI3K Inhibitor GSK1059615
Preferred_Name
PI3K Inhibitor GSK1059615
FDA_UNII_Code
07YMO87363
Contributing_Source
CTRP
FDA
Maps_To
PI3K Inhibitor GSK1059615
CAS_Registry
958852-01-2
NCI_Drug_Dictionary_ID
600076
Legacy Concept Name
PI3K_Inhibitor_GSK1059615
type
Is_Value_For_GDC_Property
subClassOf
PDQ_Open_Trial_Search_ID
600076
Semantic_Type
Organic Chemical
Pharmacologic Substance
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