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Biological and Environmental Research Ontology
Last uploaded:
December 23, 2022
| Id | http://purl.obolibrary.org/obo/NCIT_C78464
http://purl.obolibrary.org/obo/NCIT_C78464
|
|---|---|
| Preferred Name | Anti-KIR Monoclonal Antibody IPH 2101 |
| Definitions |
A human monoclonal antibody directed against the human inhibitory killer IgG-like receptor (KIR) with potential immunostimulating and antineoplastic activities. Anti-KIR monoclonal antibody IPH 2101 binds to the KIR receptor expressed on human natural killer (NK) cells, which may prevent KIR-mediated inhibition of NK cells and permit NK cell-mediated anti-tumor cytotoxicity. KIRs are surface glycoproteins that bind to major histocompatibility complex (MHC)/human leukocyte antigen (HLA) class I subtypes on target cells; binding of KIRs inhibits NK cell-mediated cytotoxicity.
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| Type | http://www.w3.org/2002/07/owl#Class |
All Properties
| definition | A human monoclonal antibody directed against the human inhibitory killer IgG-like receptor (KIR) with potential immunostimulating and antineoplastic activities. Anti-KIR monoclonal antibody IPH 2101 binds to the KIR receptor expressed on human natural killer (NK) cells, which may prevent KIR-mediated inhibition of NK cells and permit NK cell-mediated anti-tumor cytotoxicity. KIRs are surface glycoproteins that bind to major histocompatibility complex (MHC)/human leukocyte antigen (HLA) class I subtypes on target cells; binding of KIRs inhibits NK cell-mediated cytotoxicity. |
|---|---|
| prefLabel | Anti-KIR Monoclonal Antibody IPH 2101
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| label | Anti-KIR Monoclonal Antibody IPH 2101
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| PDQ_Closed_Trial_Search_ID | 599832
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| code | C78464
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| Has_Target | |
| prefixIRI | NCIT:C78464
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| in_subset |
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| Display_Name | Anti-KIR Monoclonal Antibody IPH 2101
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| Preferred_Name | Anti-KIR Monoclonal Antibody IPH 2101
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| FDA_UNII_Code | 5Q686XLG8L
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| Contributing_Source |
CTRP
FDA
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| Maps_To | Anti-KIR Monoclonal Antibody IPH 2101
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| CAS_Registry | 1000676-42-5
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| NCI_Drug_Dictionary_ID | 599832
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| Legacy Concept Name | Anti-KIR_Monoclonal_Antibody_1-7F9
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| type | |
| Is_Value_For_GDC_Property | |
| subClassOf | |
| PDQ_Open_Trial_Search_ID | 599832
|
| Semantic_Type |
Amino Acid, Peptide, or Protein
Pharmacologic Substance
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| UMLS_CUI | C2703118
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