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Biological and Environmental Research Ontology
Last uploaded:
December 23, 2022
| Id | http://purl.obolibrary.org/obo/NCIT_C78187
http://purl.obolibrary.org/obo/NCIT_C78187
|
|---|---|
| Preferred Name | Anti-CD70 Monoclonal Antibody MDX-1411 |
| Definitions |
A glycoengineered, fully human IgG1 monoclonal antibody directed against the extracellular domain of the human CD70 molecule with potential antineoplastic activity. Anti-CD70 fully human monoclonal antibody MDX-1411 selectivity binds to the extracellular domain of CD70, which may induce an antibody-dependent cellular cytotoxicity (ADCC) response against CD70-expressing tumor cells. CD70, the ligand for the costimulatory receptor CD27 and a member of the tumor necrosis factor (TNF) family, is found on renal cell carcinoma (RCC) cells among other cancer cell types.
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| Type | http://www.w3.org/2002/07/owl#Class |
All Properties
| definition | A glycoengineered, fully human IgG1 monoclonal antibody directed against the extracellular domain of the human CD70 molecule with potential antineoplastic activity. Anti-CD70 fully human monoclonal antibody MDX-1411 selectivity binds to the extracellular domain of CD70, which may induce an antibody-dependent cellular cytotoxicity (ADCC) response against CD70-expressing tumor cells. CD70, the ligand for the costimulatory receptor CD27 and a member of the tumor necrosis factor (TNF) family, is found on renal cell carcinoma (RCC) cells among other cancer cell types. |
|---|---|
| label | Anti-CD70 Monoclonal Antibody MDX-1411
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| prefLabel | Anti-CD70 Monoclonal Antibody MDX-1411
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| Legacy Concept Name | Anti-CD70_Fully_Human_Monoclonal_Antibody_MDX-1411
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| in_subset |
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| Preferred_Name | Anti-CD70 Monoclonal Antibody MDX-1411
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| Is_Value_For_GDC_Property | |
| Display_Name | Anti-CD70 Monoclonal Antibody MDX-1411
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| Maps_To | Anti-CD70 Monoclonal Antibody MDX-1411
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| PDQ_Open_Trial_Search_ID | 594769
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| Has_Target | |
| prefixIRI | NCIT:C78187
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| NCI_Drug_Dictionary_ID | 594769
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| Contributing_Source | CTRP
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| subClassOf | |
| code | C78187
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| type | |
| PDQ_Closed_Trial_Search_ID | 594769
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| Semantic_Type |
Amino Acid, Peptide, or Protein
Pharmacologic Substance
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| NCI_META_CUI | CL383579
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