Polymyxin Antibiotic

Any of the polymyxin antibiotics, cyclic peptides with long hydrophobic ends, obtained from Bacillus polymyxa strains. Polymyxin antibiotics exert their antimicrobial effect through their cationic detergent actions on cell membranes. Specifically, they bind to the negatively charged site in the lipopolysaccharide (LPS) layer of the bacterial cell membrane via electrostatic affinity with the positively charged amino groups in the cyclic peptide portion of the polymyxin antibiotic. Subsequently, the fatty acid portion of the polymyxin antibiotic dissolves in the hydrophobic region of the bacterial cell membrane. This results in an alteration in cell membrane structure, an increase in permeability for water and other molecules and disruption of cell wall integrity. This leads to bacterial cell death.

http://purl.obolibrary.org/obo/NCIT_C78160

CHEBI:59062

C78160

Any of the polymyxin antibiotics, cyclic peptides with long hydrophobic ends, obtained from Bacillus polymyxa strains. Polymyxin antibiotics exert their antimicrobial effect through their cationic detergent actions on cell membranes. Specifically, they bind to the negatively charged site in the lipopolysaccharide (LPS) layer of the bacterial cell membrane via electrostatic affinity with the positively charged amino groups in the cyclic peptide portion of the polymyxin antibiotic. Subsequently, the fatty acid portion of the polymyxin antibiotic dissolves in the hydrophobic region of the bacterial cell membrane. This results in an alteration in cell membrane structure, an increase in permeability for water and other molecules and disruption of cell wall integrity. This leads to bacterial cell death.

Polymyxin Antibiotic

Polymyxin_Antibiotic

Polymyxin Antibiotic

NCIT:C78160

Polymyxin Antibiotic

Chemical Viewed Functionally

C0032539

http://purl.obolibrary.org/obo/NCIT_C258