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Biological and Environmental Research Ontology
Last uploaded:
December 23, 2022
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| Preferred Name | Propylthiouracil | |
| Synonyms |
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| Definitions |
A thiourea derivative with antithyroid property. Propylthiouracil (PTU) interferes with the oxidation of iodine possibly by interaction with peroxidase or a peroxidase-mediated complex reaction, thereby inhibiting synthesis of thyroid hormones tri-iodothyronine (T3) and thyroxine (T4). In addition, this agent inhibits the Type I 5'-deiodinase (D1), an enzyme involved in the peripheral conversion of thyroxine to tri-iodothyronine. This results in decreased plasma triodothyronine concentrations and decreased entrance of thyroxine into cells thereby reducing thyroid hormone activity. |
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| ID |
http://purl.obolibrary.org/obo/NCIT_C781 |
|
| CAS_Registry |
51-52-5
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| CHEBI_ID |
CHEBI:8502
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| Chemical_Formula |
C7H10N2OS
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|
| code |
C781
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| Contributing_Source |
FDA
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|
| definition |
A thiourea derivative with antithyroid property. Propylthiouracil (PTU) interferes with the oxidation of iodine possibly by interaction with peroxidase or a peroxidase-mediated complex reaction, thereby inhibiting synthesis of thyroid hormones tri-iodothyronine (T3) and thyroxine (T4). In addition, this agent inhibits the Type I 5'-deiodinase (D1), an enzyme involved in the peripheral conversion of thyroxine to tri-iodothyronine. This results in decreased plasma triodothyronine concentrations and decreased entrance of thyroxine into cells thereby reducing thyroid hormone activity.
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| FDA_UNII_Code |
721M9407IY
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|
| in_subset | ||
| label |
Propylthiouracil
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| Legacy Concept Name |
Propylthiouracil
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| NCI_Drug_Dictionary_ID |
39288
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| NSC Number |
70461
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|
| PDQ_Closed_Trial_Search_ID |
39288
|
|
| PDQ_Open_Trial_Search_ID |
39288
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|
| Preferred_Name |
Propylthiouracil
|
|
| prefixIRI |
NCIT:C781
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|
| prefLabel |
Propylthiouracil
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| Semantic_Type |
Pharmacologic Substance Nucleic Acid, Nucleoside, or Nucleotide
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| UMLS_CUI |
C0033511
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| subClassOf |
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