Biological and Environmental Research Ontology

Last uploaded: December 23, 2022
Id http://purl.obolibrary.org/obo/NCIT_C78085
http://purl.obolibrary.org/obo/NCIT_C78085
Preferred Name

Methoxyamine Hydrochloride
Definitions
The hydrochloride salt form of methoxyamine, an alkoxyamine with potential chemotherapeutic adjuvant activity. Methoxyamine covalently binds to apurinic/apyrimidinic DNA damage sites and thereby inhibits base excision repair (BER) process, which may prevent repair of DNA strand breaks and result in an induction of apoptosis. This agent may potentiate the anti-tumor activity of alkylating agents.
Type http://www.w3.org/2002/07/owl#Class

All Properties

definition

The hydrochloride salt form of methoxyamine, an alkoxyamine with potential chemotherapeutic adjuvant activity. Methoxyamine covalently binds to apurinic/apyrimidinic DNA damage sites and thereby inhibits base excision repair (BER) process, which may prevent repair of DNA strand breaks and result in an induction of apoptosis. This agent may potentiate the anti-tumor activity of alkylating agents.
prefLabel
Methoxyamine Hydrochloride
label
Methoxyamine Hydrochloride
code
C78085
prefixIRI
NCIT:C78085
in_subset
Display_Name
Methoxyamine Hydrochloride
Preferred_Name
Methoxyamine Hydrochloride
FDA_UNII_Code
203546OLMF
Contributing_Source
CTRP
FDA
Chemical_Formula
CH5NO.HCl
Maps_To
Methoxyamine Hydrochloride
CAS_Registry
593-56-6
NSC Number
3801
Legacy Concept Name
Methoxyamine_Hydrochloride
Has_Free_Acid_Or_Base_Form
type
ALT_DEFINITION
A substance being studied in the treatment of cancer. It blocks the ability of a cell to repair damage to its DNA and may kill cancer cells. It may also help some anticancer drugs work better. It is a type of antineoplastic agent.
Is_Value_For_GDC_Property
subClassOf
Semantic_Type
Pharmacologic Substance
UMLS_CUI
C0951345
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