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Biological and Environmental Research Ontology
Last uploaded:
December 23, 2022
| Id | http://purl.obolibrary.org/obo/NCIT_C78084
http://purl.obolibrary.org/obo/NCIT_C78084
|
|---|---|
| Preferred Name | Methoxyamine |
| Definitions |
An orally bioavailable small molecule inhibitor with potential adjuvant activity. Methoxyamine covalently binds to apurinic/apyrimidinic (AP) DNA damage sites and inhibits base excision repair (BER), which may result in an increase in DNA strand breaks and apoptosis. This agent may potentiate the anti-tumor activity of alkylating agents.
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| Type | http://www.w3.org/2002/07/owl#Class |
All Properties
| definition | An orally bioavailable small molecule inhibitor with potential adjuvant activity. Methoxyamine covalently binds to apurinic/apyrimidinic (AP) DNA damage sites and inhibits base excision repair (BER), which may result in an increase in DNA strand breaks and apoptosis. This agent may potentiate the anti-tumor activity of alkylating agents. |
|---|---|
| prefLabel | Methoxyamine
|
| label | Methoxyamine
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| Has_Salt_Form | |
| PDQ_Closed_Trial_Search_ID | 599836
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| code | C78084
|
| prefixIRI | NCIT:C78084
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| in_subset |
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| Display_Name | Methoxyamine
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| Preferred_Name | Methoxyamine
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| FDA_UNII_Code | 9TZH4WY30J
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| Contributing_Source |
CTRP
FDA
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| Chemical_Formula | CH5NO
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| Maps_To | Methoxyamine
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| CAS_Registry | 67-62-9
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| NCI_Drug_Dictionary_ID | 599836
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| Legacy Concept Name | Methoxyamine
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| type | |
| Is_Value_For_GDC_Property | |
| subClassOf | |
| PDQ_Open_Trial_Search_ID | 599836
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| Semantic_Type |
Organic Chemical
Pharmacologic Substance
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| UMLS_CUI | C0066156
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