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Biological and Environmental Research Ontology
Last uploaded:
December 23, 2022
| Id | http://purl.obolibrary.org/obo/NCIT_C77885
http://purl.obolibrary.org/obo/NCIT_C77885
|
|---|---|
| Preferred Name | Yttrium Y 90 Anti-CEA Monoclonal Antibody cT84.66 |
| Definitions |
A radioimmunoconjugate comprised of a chimeric monoclonal antibody against human carcinoembryonic antigen (CEA) conjugated with the radioisotope yttrium 90 (Y-90) via the chelator tetra-azacyclododecanetetra-acetic acid (DOTA) with potential antineoplastic activity. The antibody moiety of yttrium Y90 DOTA anti-CEA monoclonal antibody cT84.66 binds to cells expressing the CEA antigen. Upon cellular internalization, this agent selectively delivers a cytotoxic dose of beta radiation. CEA, a tumor associated antigen, is overexpressed in many cancer types, including gastrointestinal, breast, non-small cell lung, and thyroid cancers.
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| Type | http://www.w3.org/2002/07/owl#Class |
All Properties
| definition | A radioimmunoconjugate comprised of a chimeric monoclonal antibody against human carcinoembryonic antigen (CEA) conjugated with the radioisotope yttrium 90 (Y-90) via the chelator tetra-azacyclododecanetetra-acetic acid (DOTA) with potential antineoplastic activity. The antibody moiety of yttrium Y90 DOTA anti-CEA monoclonal antibody cT84.66 binds to cells expressing the CEA antigen. Upon cellular internalization, this agent selectively delivers a cytotoxic dose of beta radiation. CEA, a tumor associated antigen, is overexpressed in many cancer types, including gastrointestinal, breast, non-small cell lung, and thyroid cancers. |
|---|---|
| prefLabel | Yttrium Y 90 Anti-CEA Monoclonal Antibody cT84.66
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| label | Yttrium Y 90 Anti-CEA Monoclonal Antibody cT84.66
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| NCI_META_CUI | CL387153
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| PDQ_Closed_Trial_Search_ID | 592860
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| code | C77885
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| Has_Target | |
| prefixIRI | NCIT:C77885
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| in_subset |
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| Display_Name | Yttrium Y 90 Anti-CEA Monoclonal Antibody cT84.66
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| Preferred_Name | Yttrium Y 90 Anti-CEA Monoclonal Antibody cT84.66
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| Contributing_Source | CTRP
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| Maps_To | Yttrium Y 90 Anti-CEA Monoclonal Antibody cT84.66
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| NCI_Drug_Dictionary_ID | 592860
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| Legacy Concept Name | Yttrium_Y_90_DOTA_Anti-CEA_Monoclonal_Antibody_cT84_66
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| type | |
| Is_Value_For_GDC_Property | |
| subClassOf | |
| PDQ_Open_Trial_Search_ID | 592860
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| Semantic_Type |
Amino Acid, Peptide, or Protein
Pharmacologic Substance
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