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Biological and Environmental Research Ontology
Last uploaded:
December 23, 2022
| Id | http://purl.obolibrary.org/obo/NCIT_C77876
http://purl.obolibrary.org/obo/NCIT_C77876
|
|---|---|
| Preferred Name | Glesatinib |
| Definitions |
An orally bioavailable, small-molecule, multitargeted tyrosine kinase inhibitor with potential antineoplastic activity. Glesatinib binds to and inhibits the phosphorylation of several receptor tyrosine kinases (RTKs), including the c-Met receptor (hepatocyte growth factor receptor); the Tek/Tie-2 receptor; vascular endothelial growth factor receptor (VEGFR) types 1, 2, and 3; and the macrophage-stimulating 1 receptor (MST1R or RON). Inhibition of these RTKs and their downstream signaling pathways may result in the inhibition of tumor angiogenesis and tumor cell proliferation in tumors overexpressing these RTKs.
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| Type | http://www.w3.org/2002/07/owl#Class |
All Properties
| definition | An orally bioavailable, small-molecule, multitargeted tyrosine kinase inhibitor with potential antineoplastic activity. Glesatinib binds to and inhibits the phosphorylation of several receptor tyrosine kinases (RTKs), including the c-Met receptor (hepatocyte growth factor receptor); the Tek/Tie-2 receptor; vascular endothelial growth factor receptor (VEGFR) types 1, 2, and 3; and the macrophage-stimulating 1 receptor (MST1R or RON). Inhibition of these RTKs and their downstream signaling pathways may result in the inhibition of tumor angiogenesis and tumor cell proliferation in tumors overexpressing these RTKs. |
|---|---|
| prefLabel | Glesatinib
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| label | Glesatinib
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| NCI_META_CUI | CL383618
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| PDQ_Closed_Trial_Search_ID | 597305
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| code | C77876
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| Has_Target | |
| prefixIRI | NCIT:C77876
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| in_subset |
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| Display_Name | Glesatinib
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| Preferred_Name | Glesatinib
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| FDA_UNII_Code | 7Q29OXD98N
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| Contributing_Source |
CTRP
FDA
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| Maps_To | Glesatinib
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| CAS_Registry | 936694-12-1
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| NCI_Drug_Dictionary_ID | 597305
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| Legacy Concept Name | Tyrosine_Kinase_Inhibitor_MGCD265
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| type | |
| Is_Value_For_GDC_Property | |
| subClassOf | |
| PDQ_Open_Trial_Search_ID | 597305
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| Semantic_Type |
Organic Chemical
Pharmacologic Substance
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