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Biological and Environmental Research Ontology
Last uploaded:
December 23, 2022
| Id | http://purl.obolibrary.org/obo/NCIT_C77866
http://purl.obolibrary.org/obo/NCIT_C77866
|
|---|---|
| Preferred Name | Multitargeted Tyrosine Kinase Inhibitor JNJ-26483327 |
| Definitions |
An orally bioavailable, small-molecule, multitargeted reversible tyrosine kinase inhibitor with potential antineoplastic activity. Multitargeted tyrosine kinase inhibitor JNJ-26483327 binds to and inhibits several members of the epidermal growth factor receptor (EGFR) family, including EGFR, HER2 and HER4; Src family kinases (Lyn, Yes, Fyn, Lck and Src); and vascular endothelial growth factor receptor type 3 (VEGFR3). By inhibiting several different signaling molecules that play crucial roles at various stages in tumorigenesis, this agent may inhibit tumor growth, invasion, migration and metastasis. In addition, JNJ-26483327 crosses the blood-brain barrier (BBB).
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| Type | http://www.w3.org/2002/07/owl#Class |
All Properties
| definition | An orally bioavailable, small-molecule, multitargeted reversible tyrosine kinase inhibitor with potential antineoplastic activity. Multitargeted tyrosine kinase inhibitor JNJ-26483327 binds to and inhibits several members of the epidermal growth factor receptor (EGFR) family, including EGFR, HER2 and HER4; Src family kinases (Lyn, Yes, Fyn, Lck and Src); and vascular endothelial growth factor receptor type 3 (VEGFR3). By inhibiting several different signaling molecules that play crucial roles at various stages in tumorigenesis, this agent may inhibit tumor growth, invasion, migration and metastasis. In addition, JNJ-26483327 crosses the blood-brain barrier (BBB). |
|---|---|
| prefLabel | Multitargeted Tyrosine Kinase Inhibitor JNJ-26483327
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| label | Multitargeted Tyrosine Kinase Inhibitor JNJ-26483327
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| PDQ_Closed_Trial_Search_ID | 596693
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| code | C77866
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| prefixIRI | NCIT:C77866
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| in_subset | |
| Preferred_Name | Multitargeted Tyrosine Kinase Inhibitor JNJ-26483327
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| FDA_UNII_Code | 16720VER1H
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| Contributing_Source | FDA
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| Maps_To | Multitargeted Tyrosine Kinase Inhibitor JNJ-26483327
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| CAS_Registry | 807640-87-5
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| NCI_Drug_Dictionary_ID | 596693
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| Legacy Concept Name | Multitargeted_Kinase_Inhibitor_JNJ-26483327
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| type | |
| Is_Value_For_GDC_Property | |
| subClassOf | |
| PDQ_Open_Trial_Search_ID | 596693
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| Semantic_Type |
Organic Chemical
Pharmacologic Substance
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| UMLS_CUI | C2713088
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