Biological and Environmental Research Ontology

Last uploaded: December 23, 2022
Id http://purl.obolibrary.org/obo/NCIT_C77856
http://purl.obolibrary.org/obo/NCIT_C77856
Preferred Name

Tyroserleutide
Definitions
A tripeptide consisting of tyrosine, serine, and leucine with potential antineoplastic activity. Although the mechanism of its antitumor activity has yet to be fully elucidated, tyroserleutide appears to inhibit the expression of ICAM-1 (CD54), a cell adhesion factor of the immunoglobulin (Ig) superfamily that plays an important role in the invasion, adhesion, and metastasis of tumor cells. In addition, this agent may influence the Ca2+/calmodulin pathway, inhibiting phosphatidylinositol 3 kinase (PI3K); PI3K is upregulated in tumor cells and is involved in cellular proliferation.
Type http://www.w3.org/2002/07/owl#Class

All Properties

definition

A tripeptide consisting of tyrosine, serine, and leucine with potential antineoplastic activity. Although the mechanism of its antitumor activity has yet to be fully elucidated, tyroserleutide appears to inhibit the expression of ICAM-1 (CD54), a cell adhesion factor of the immunoglobulin (Ig) superfamily that plays an important role in the invasion, adhesion, and metastasis of tumor cells. In addition, this agent may influence the Ca2+/calmodulin pathway, inhibiting phosphatidylinositol 3 kinase (PI3K); PI3K is upregulated in tumor cells and is involved in cellular proliferation.
prefLabel
Tyroserleutide
label
Tyroserleutide
PDQ_Closed_Trial_Search_ID
593430
code
C77856
prefixIRI
NCIT:C77856
in_subset
Preferred_Name
Tyroserleutide
FDA_UNII_Code
L9TIM50J8N
Contributing_Source
FDA
Maps_To
Tyroserleutide
CAS_Registry
138168-48-6
NCI_Drug_Dictionary_ID
593430
Legacy Concept Name
Tyroserleutide
type
Is_Value_For_GDC_Property
subClassOf
PDQ_Open_Trial_Search_ID
593430
Semantic_Type
Amino Acid, Peptide, or Protein
Pharmacologic Substance
UMLS_CUI
C1451018
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