Link to this page
Biological and Environmental Research Ontology
Last uploaded:
December 23, 2022
| Id | http://purl.obolibrary.org/obo/NCIT_C77600
http://purl.obolibrary.org/obo/NCIT_C77600
|
|---|---|
| Preferred Name | Disufenton Sodium |
| Definitions |
A disulfonyl derivative of phenyl-tert-butyl nitrone (PBN), with potential anti-glioma activity. Although the exact mechanism(s) of action of OKN007 are still largely unknown, this agent appears to inhibit cancer cell proliferation and migration. This agent appears to inhibit the activity of sulfatase 2 (SULF2), a highly specific endoglucosamine-6-sulfatase that is overexpressed in the extracellular matrix of cancer cells and catalyzes the removal of sulfate from the 6-O-sulfate esters of heparin. In addition, OKN007 may induce changes in tumor metabolism and scavenge free radicals.
|
| Type | http://www.w3.org/2002/07/owl#Class |
All Properties
| definition | A disulfonyl derivative of phenyl-tert-butyl nitrone (PBN), with potential anti-glioma activity. Although the exact mechanism(s) of action of OKN007 are still largely unknown, this agent appears to inhibit cancer cell proliferation and migration. This agent appears to inhibit the activity of sulfatase 2 (SULF2), a highly specific endoglucosamine-6-sulfatase that is overexpressed in the extracellular matrix of cancer cells and catalyzes the removal of sulfate from the 6-O-sulfate esters of heparin. In addition, OKN007 may induce changes in tumor metabolism and scavenge free radicals. |
|---|---|
| prefLabel | Disufenton Sodium
|
| label | Disufenton Sodium
|
| code | C77600
|
| prefixIRI | NCIT:C77600
|
| in_subset |
See more
See less
|
| Display_Name | Disufenton Sodium
|
| Preferred_Name | Disufenton Sodium
|
| FDA_UNII_Code | 7M1J3HN9VO
|
| Contributing_Source |
CTRP
FDA
|
| Chemical_Formula | C11H13NO7S2.2Na
|
| Maps_To | PBN Derivative OKN-007
|
| CAS_Registry | 168021-79-2
|
| NCI_Drug_Dictionary_ID | 739669
|
| Legacy Concept Name | Disufenton_Sodium
|
| type | |
| Is_Value_For_GDC_Property | |
| subClassOf | |
| Semantic_Type | Pharmacologic Substance
|
| UMLS_CUI | C1701245
|
| Delete | Subject | Author | Type | Created |
|---|---|---|---|---|
| No notes to display |