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Biological and Environmental Research Ontology
Last uploaded:
December 23, 2022
| Id | http://purl.obolibrary.org/obo/NCIT_C77518
http://purl.obolibrary.org/obo/NCIT_C77518
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|---|---|
| Preferred Name | Ispinesib Mesylate |
| Definitions |
The mesylate salt form of ispinesib, a synthetic small molecule, derived from quinazolinone, and kinesin spindle protein (KSP) inhibitor, with antineoplastic activity. Ispinesib selectively inhibits KSP and prevents its binding to microtubules, resulting in inhibition of mitotic spindle assembly, induction of cell cycle arrest during the M-phase, and cell death in tumor cells that are actively dividing.
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| Type | http://www.w3.org/2002/07/owl#Class |
All Properties
| definition | The mesylate salt form of ispinesib, a synthetic small molecule, derived from quinazolinone, and kinesin spindle protein (KSP) inhibitor, with antineoplastic activity. Ispinesib selectively inhibits KSP and prevents its binding to microtubules, resulting in inhibition of mitotic spindle assembly, induction of cell cycle arrest during the M-phase, and cell death in tumor cells that are actively dividing. |
|---|---|
| prefLabel | Ispinesib Mesylate
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| label | Ispinesib Mesylate
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| code | C77518
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| prefixIRI | NCIT:C77518
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| in_subset | |
| Preferred_Name | Ispinesib Mesylate
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| FDA_UNII_Code | R6ZMD4UH3D
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| Contributing_Source | FDA
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| Chemical_Formula | C30H33ClN4O2.CH4O3S
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| Maps_To | Ispinesib Mesylate
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| CAS_Registry | 514820-03-2
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| Legacy Concept Name | Ispinesib_Mesylate
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| Has_Free_Acid_Or_Base_Form | |
| type | |
| Is_Value_For_GDC_Property | |
| subClassOf | |
| Semantic_Type | Pharmacologic Substance
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| UMLS_CUI | C2697824
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