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Biological and Environmental Research Ontology
Last uploaded:
December 23, 2022
| Id | http://purl.obolibrary.org/obo/NCIT_C77403
http://purl.obolibrary.org/obo/NCIT_C77403
|
|---|---|
| Preferred Name | Ketotrexate |
| Definitions |
A folic acid antagonist and mammalian dihydrofolate reductase inhibitor with antineoplastic activity. Ketotrexate inhibits dihydrofolate reductase, an enzyme that reduces dihydrofolic acid to tetrahydrofolic acid which is essential for the synthesis of purine nucleotides and thymidylate. By depleting tetrahydrofolic acid availability, DNA synthesis is halted.
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| Type | http://www.w3.org/2002/07/owl#Class |
All Properties
| definition | A folic acid antagonist and mammalian dihydrofolate reductase inhibitor with antineoplastic activity. Ketotrexate inhibits dihydrofolate reductase, an enzyme that reduces dihydrofolic acid to tetrahydrofolic acid which is essential for the synthesis of purine nucleotides and thymidylate. By depleting tetrahydrofolic acid availability, DNA synthesis is halted. |
|---|---|
| prefLabel | Ketotrexate
|
| label | Ketotrexate
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| code | C77403
|
| prefixIRI | NCIT:C77403
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| in_subset | |
| Preferred_Name | Ketotrexate
|
| FDA_UNII_Code | 504RN634MM
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| Contributing_Source | FDA
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| Chemical_Formula | C21H27N7O6
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| Maps_To | Ketotrexate
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| CAS_Registry | 877017-93-1
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| Legacy Concept Name | Ketotrexate
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| type | |
| Is_Value_For_GDC_Property | |
| subClassOf | |
| Semantic_Type | Pharmacologic Substance
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| UMLS_CUI | C2697842
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