loading...| Preferred Name | Darunavir Ethanolate | |
| Synonyms |
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| Definitions |
The ethanolate form of darunavir, a human immunodeficiency virus type 1 (HIV-1) protease nonpeptidic inhibitor, with activity against HIV. Upon oral administration, darunavir selectively targets and binds to the active site of HIV-1 protease, and inhibits the dimerization and catalytic activity of HIV-1 protease. This inhibits the proteolytic cleavage of viral Gag and Gag-Pol polyproteins in HIV-infected cells. This inhibition leads to the production of immature, non-infectious viral proteins that are unable to form mature virions, and prevents HIV replication. |
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| ID |
http://purl.obolibrary.org/obo/NCIT_C77389 |
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| CAS_Registry |
635728-49-3 |
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| Chemical_Formula |
C27H37N3O7S.C2H6O |
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| code |
C77389 |
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| Contributing_Source |
FDA |
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| definition |
The ethanolate form of darunavir, a human immunodeficiency virus type 1 (HIV-1) protease nonpeptidic inhibitor, with activity against HIV. Upon oral administration, darunavir selectively targets and binds to the active site of HIV-1 protease, and inhibits the dimerization and catalytic activity of HIV-1 protease. This inhibits the proteolytic cleavage of viral Gag and Gag-Pol polyproteins in HIV-infected cells. This inhibition leads to the production of immature, non-infectious viral proteins that are unable to form mature virions, and prevents HIV replication. |
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| FDA_UNII_Code |
33O78XF0BW |
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| in_subset | ||
| label |
Darunavir Ethanolate |
|
| Legacy Concept Name |
Darunavir_Ethanolate |
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| Preferred_Name |
Darunavir Ethanolate |
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| prefixIRI |
NCIT:C77389 |
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| prefLabel |
Darunavir Ethanolate |
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| Semantic_Type |
Pharmacologic Substance |
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| UMLS_CUI |
C1725651 |
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| subClassOf |