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Biological and Environmental Research Ontology
Last uploaded:
December 23, 2022
| Id | http://purl.obolibrary.org/obo/NCIT_C77218
http://purl.obolibrary.org/obo/NCIT_C77218
|
|---|---|
| Preferred Name | Bisantrene Hydrochloride |
| Definitions |
The hydrochloride salt of an anthracenyl bishydrazone with antineoplastic activity. Bisantrene intercalates with and disrupts the helical structure of DNA, resulting in DNA single-strand breaks, DNA-protein crosslinking, and inhibition of DNA replication. This agent is similar to doxorubicin in activity, but unlike doxorubicin, does not exhibit cardiotoxicity.
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| Type | http://www.w3.org/2002/07/owl#Class |
All Properties
| definition | The hydrochloride salt of an anthracenyl bishydrazone with antineoplastic activity. Bisantrene intercalates with and disrupts the helical structure of DNA, resulting in DNA single-strand breaks, DNA-protein crosslinking, and inhibition of DNA replication. This agent is similar to doxorubicin in activity, but unlike doxorubicin, does not exhibit cardiotoxicity. |
|---|---|
| prefLabel | Bisantrene Hydrochloride
|
| label | Bisantrene Hydrochloride
|
| PDQ_Closed_Trial_Search_ID | 39136
|
| code | C77218
|
| prefixIRI | NCIT:C77218
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| in_subset | |
| Preferred_Name | Bisantrene Hydrochloride
|
| FDA_UNII_Code | 74GNV897RO
|
| Contributing_Source | FDA
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| Chemical_Formula | C22H22N8.2HCl
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| Maps_To | Bisantrene Hydrochloride
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| CAS_Registry | 71439-68-4
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| NSC Number | 337766
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| NCI_Drug_Dictionary_ID | 39136
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| Legacy Concept Name | Bisantrene_Hydrochloride
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| Has_Free_Acid_Or_Base_Form | |
| type | |
| Is_Value_For_GDC_Property | |
| subClassOf | |
| PDQ_Open_Trial_Search_ID | 39136
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| Semantic_Type |
Organic Chemical
Pharmacologic Substance
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| UMLS_CUI | C0955176
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| Delete | Subject | Author | Type | Created |
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