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Biological and Environmental Research Ontology
Last uploaded:
December 23, 2022
| Id | http://purl.obolibrary.org/obo/NCIT_C77067
http://purl.obolibrary.org/obo/NCIT_C77067
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|---|---|
| Preferred Name | Tasidotin |
| Definitions |
A third generation, synthetic, water-soluble, pentapeptide analog of the marine depsipeptide dolastatin 15, with potential antimitotic and antineoplastic activities. Tasidotin and its metabolite, tasidotin C-carboxylate, suppress the dynamic instability behavior of the microtubules through a reduction of the shortening rate (disassembly); reduction of the switching frequency from growth to shortening; and by reducing microtubules growth time. This may eventually result in a reduction of cell growth.
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| Type | http://www.w3.org/2002/07/owl#Class |
All Properties
| definition | A third generation, synthetic, water-soluble, pentapeptide analog of the marine depsipeptide dolastatin 15, with potential antimitotic and antineoplastic activities. Tasidotin and its metabolite, tasidotin C-carboxylate, suppress the dynamic instability behavior of the microtubules through a reduction of the shortening rate (disassembly); reduction of the switching frequency from growth to shortening; and by reducing microtubules growth time. This may eventually result in a reduction of cell growth. |
|---|---|
| prefLabel | Tasidotin
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| label | Tasidotin
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| Has_Salt_Form | |
| code | C77067
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| prefixIRI | NCIT:C77067
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| in_subset | |
| Preferred_Name | Tasidotin
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| FDA_UNII_Code | 05G07285DK
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| Contributing_Source | FDA
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| Chemical_Formula | C32H58N6O5
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| Maps_To | Tasidotin
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| CAS_Registry | 192658-64-3
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| Legacy Concept Name | Tasidotin
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| type | |
| Is_Value_For_GDC_Property | |
| subClassOf | |
| Semantic_Type | Pharmacologic Substance
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| UMLS_CUI | C1610484
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