Link to this page
Biological and Environmental Research Ontology
Last uploaded:
December 23, 2022
| Id | http://purl.obolibrary.org/obo/NCIT_C770
http://purl.obolibrary.org/obo/NCIT_C770
|
|---|---|
| Preferred Name | Prednisone |
| Definitions |
A synthetic glucocorticoid with anti-inflammatory and immunomodulating properties. After cell surface receptor attachment and cell entry, prednisone enters the nucleus where it binds to and activates specific nuclear receptors, resulting in an altered gene expression and inhibition of proinflammatory cytokine production. This agent also decreases the number of circulating lymphocytes, induces cell differentiation, and stimulates apoptosis in sensitive tumor cell populations.
|
| Type | http://www.w3.org/2002/07/owl#Class |
All Properties
| definition | A synthetic glucocorticoid with anti-inflammatory and immunomodulating properties. After cell surface receptor attachment and cell entry, prednisone enters the nucleus where it binds to and activates specific nuclear receptors, resulting in an altered gene expression and inhibition of proinflammatory cytokine production. This agent also decreases the number of circulating lymphocytes, induces cell differentiation, and stimulates apoptosis in sensitive tumor cell populations. |
|---|---|
| prefLabel | Prednisone
|
| label | Prednisone
|
| CHEBI_ID | CHEBI:8382
|
| PDQ_Closed_Trial_Search_ID | 42487
|
| code | C770
|
| prefixIRI | NCIT:C770
|
| in_subset |
See more
See less
|
| Display_Name | Prednisone
|
| Preferred_Name | Prednisone
|
| FDA_UNII_Code | VB0R961HZT
|
| Contributing_Source |
CTRP
DIPG/DMG
FDA
PCDC
|
| Chemical_Formula | C21H26O5
|
| Maps_To | Prednisone
|
| CAS_Registry | 53-03-2
|
| NSC Number | 10023
|
| NCI_Drug_Dictionary_ID | 42487
|
| Legacy Concept Name | Prednisone
|
| type | |
| ALT_DEFINITION | A drug used to lessen inflammation and lower the body's immune response. It is used with other drugs to treat leukemia and lymphoma and other types of cancer. It is also used alone or with other drugs to prevent or treat many other conditions. These include conditions related to cancer, such as anemia (a low level of red blood cells), allergic reactions, and loss of appetite. Prednisone is a type of therapeutic glucocorticoid.
|
| Is_Value_For_GDC_Property | |
| subClassOf | |
| PDQ_Open_Trial_Search_ID | 42487
|
| Accepted_Therapeutic_Use_For | Inflammatory conditions; Allergic conditions; Hematologic conditions; Neoplastic conditions; Autoimmune conditions; Replacement therapy in adrenal insufficiency
|
| Semantic_Type |
Organic Chemical
Pharmacologic Substance
|
| UMLS_CUI | C0032952
|
| Delete | Subject | Author | Type | Created |
|---|---|---|---|---|
| No notes to display |